Møller P
Acta Med Scand. 1985;217(1):85-8.
The frequency of cardiac conduction disturbance in ankylosing spondylitis is discussed. Risk of such disturbance in the patients' relatives is, to our knowledge, not known. To examine these problems, ECG records of 99 patients with ankylosing spondylitis and 132 of their adult first degree relatives were obtained. P-R intervals were determined by standardized methods and compared with P-R intervals of the controls. The distribution of P-R intervals both in the patients and their relatives was close to the controls'. Four cases of first degree AV block were found among the patients (P-R intervals 0.21-0.26 sec), one of them had aortic valve insufficiency. The single case of pronounced conduction delay (P-R interval 0.42 sec) was recorded in an otherwise healthy HLA B27-positive relative. One male secondary case of ankylosing spondylitis had a P-R interval of 0.22 sec. Patients who had experienced acute anterior uveitis had relatively long P-R intervals, while patients with psoriasis had relatively short P-R intervals. The conclusion was that cardiac conduction disturbance was not frequent in patients with ankylosing spondylitis or in their relatives.
本文讨论了强直性脊柱炎患者心脏传导障碍的发生率。据我们所知，此类障碍在患者亲属中的风险尚不清楚。为研究这些问题，我们获取了99例强直性脊柱炎患者及其132名成年一级亲属的心电图记录。采用标准化方法测定P-R间期，并与对照组的P-R间期进行比较。患者及其亲属的P-R间期分布与对照组相近。在患者中发现4例一度房室传导阻滞（P-R间期0.21 - 0.26秒），其中1例合并主动脉瓣关闭不全。在一名健康的HLA B27阳性亲属中记录到1例明显的传导延迟（P-R间期0.42秒）。1例强直性脊柱炎男性继发患者的P-R间期为0.22秒。曾患急性前葡萄膜炎的患者P-R间期相对较长，而患银屑病的患者P-R间期相对较短。结论是，强直性脊柱炎患者及其亲属中，心脏传导障碍并不常见。
