Beijing Life Science Academy, Beijing, China.
Department of Pathology, Affiliated Hospital of Hebei University, Baoding, China.
Animal Model Exp Med. 2024 Apr;7(2):106-113. doi: 10.1002/ame2.12414.
Androgenic alopecia (AGA) is the most common type of hair loss in men, and there are many studies on the treatment of hair loss by platelet-rich plasma (PRP). The human scalp contains a huge microbiome, but its role in the process of hair loss remains unclear, and the relationship between PRP and the microbiome needs further study. Therefore, the purpose of this study was to investigate the effect of PRP treatment on scalp microbiota composition.
We performed PRP treatment on 14 patients with AGA, observed their clinical efficacy, and collected scalp swab samples before and after treatment. The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.
The results showed that PRP was effective in the treatment of AGA patients, and the hair growth increased significantly. The results of relative abundance analysis of microbiota showed that after treatment, g_Cutibacterium increased and g_Staphylococcus decreased, which played a stable role in scalp microbiota. In addition, g_Lawsonella decreased, indicating that the scalp oil production decreased after treatment.
The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.
雄激素性脱发（AGA）是男性最常见的脱发类型，已有许多关于富血小板血浆（PRP）治疗脱发的研究。人类头皮含有庞大的微生物群，但它在脱发过程中的作用尚不清楚，PRP 与微生物群之间的关系需要进一步研究。因此，本研究旨在探讨 PRP 治疗对头皮微生物群落组成的影响。
我们对 14 例 AGA 患者进行了 PRP 治疗，观察了他们的临床疗效，并在治疗前后采集了头皮拭子样本。通过扩增 16s RNA 基因的 V3-V4 区并进行细菌鉴定，对治疗前后 AGA 患者的头皮微生物群进行了特征描述。
结果表明，PRP 对 AGA 患者有效，毛发生长明显增加。微生物群落相对丰度分析结果表明，治疗后 g_Cutibacterium 增加，g_Staphylococcus 减少，在头皮微生物群中发挥稳定作用。此外，g_Lawsonella 减少，表明治疗后头皮油脂产生减少。
这些发现表明，PRP 可能通过头皮微生物群再平衡来发挥治疗 AGA 的作用。
