Schleifer S J, Keller S E, Siris S G, Davis K L, Stein M
Arch Gen Psychiatry. 1985 Feb;42(2):129-33. doi: 10.1001/archpsyc.1985.01790250023003.
Mitogen-induced lymphocyte stimulation responses in ambulatory patients with major depressive disorder did not differ from those of matched controls. Lymphocyte responses in hospitalized schizophrenic patients and in patients hospitalized for elective herniorrhaphy similarly did not differ from responses of controls. The number of peripheral-blood T cells was decreased among the ambulatory depressed patients but not in the schizophrenic patients. These findings, together with previously reported decreased lymphocyte function in hospitalized depressed patients, suggest that decreased lymphocyte function is associated specifically with depression and not related to hospital effects or nonspecifically to other psychiatric disorders. The results also suggest that altered immunity in depression may be related to severity of depressive symptoms.
门诊重性抑郁障碍患者中，有丝分裂原诱导的淋巴细胞刺激反应与匹配的对照组并无差异。住院精神分裂症患者以及因择期疝气修补术住院的患者的淋巴细胞反应同样与对照组无差异。门诊抑郁患者外周血T细胞数量减少，但精神分裂症患者未出现此情况。这些发现，连同先前报道的住院抑郁患者淋巴细胞功能下降，表明淋巴细胞功能下降与抑郁特异性相关，与住院影响无关，也并非与其他精神障碍非特异性相关。结果还表明，抑郁症中免疫改变可能与抑郁症状的严重程度有关。
