Kronfol Z, House J D, Silva J, Greden J, Carroll B J
Br J Psychiatry. 1986 Jan;148:70-3. doi: 10.1192/bjp.148.1.70.
An impairment in lymphocyte response to mitogen stimulation, a correlate of cell-mediated immunity, has been reported in patients with depressive illness. To investigate whether such impairment in lymphocyte function is related to excessive secretion of cortisol, an immunosuppressive hormone, we compared mitogen-induced lymphocyte proliferation in three groups of subjects: depressed patients with elevated 24-hour urinary free cortisol (UFC) excretion; depressed patients with normal UFC excretion; and normal controls. Depressed patients in both groups showed significant reductions in lymphocyte mitogenic activity, in comparison with the normal controls, but the two depressive groups did not significantly differ from each other in their lymphocytic responses to any of the mitogens used. Furthermore, no significant correlations were found, within depressed patients, between UFC excretion and lymphocyte mitogenic responses. Depression is therefore associated with an impairment in lymphocyte function that cannot be explained solely on the basis of increased cortisol secretion.
据报道，抑郁症患者存在淋巴细胞对丝裂原刺激反应的损害，这是细胞介导免疫的一个相关指标。为了研究这种淋巴细胞功能损害是否与免疫抑制激素皮质醇的过度分泌有关，我们比较了三组受试者丝裂原诱导的淋巴细胞增殖情况：24小时尿游离皮质醇（UFC）排泄升高的抑郁症患者；UFC排泄正常的抑郁症患者；以及正常对照组。与正常对照组相比，两组抑郁症患者的淋巴细胞有丝分裂活性均显著降低，但两个抑郁症组对所用任何丝裂原的淋巴细胞反应彼此之间无显著差异。此外，在抑郁症患者中，未发现UFC排泄与淋巴细胞有丝分裂反应之间存在显著相关性。因此，抑郁症与淋巴细胞功能损害有关，而这种损害不能仅基于皮质醇分泌增加来解释。
