新冠疫情对英国慢性乙型肝炎病毒（HBV）感染成人常规监测的影响。
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK.
作者信息
Campbell Cori, Wang Tingyan, Smith David A, Freeman Oliver, Noble Theresa, Várnai Kinga A, Harris Steve, Salih Hizni, Roadknight Gail, Little Stephanie, Glampson Ben, Mercuri Luca, Papadimitriou Dimitri, Jones Christopher R, Taylor Vince, Chaudhry Afzal, Phan Hang, Borca Florina, Olza Josune, Warricker Frazer, Romão Luis, Ramlakhan David, English Louise, Klenerman Paul, Andersson Monique I, Collier Jane, Nastouli Eleni, Khakoo Salim I, Gelson William, Cooke Graham S, Woods Kerrie, Davies Jim, Barnes Eleanor, Matthews Philippa C
机构信息
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
出版信息
Wellcome Open Res. 2023 Nov 15;7:51. doi: 10.12688/wellcomeopenres.17522.2. eCollection 2022.
BACKGROUND
To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load).
METHODS
We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts.
RESULTS
We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had ≥1 measurement annually, and the mean number of measurements per patient.
CONCLUSIONS
These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.
背景
为了确定新冠疫情对英国医院随访的慢性乙型肝炎病毒（HBV）感染人群的影响，我们对用于常规监测的生物标志物（丙氨酸转氨酶[ALT]和HBV病毒载量）的检测覆盖率和频率进行了量化。
方法
我们使用了来自英国国家卫生研究院（NIHR）健康信息协作组织（HIC）管道的匿名电子健康记录数据，该数据代表了英国五个国民健康服务（NHS）信托机构。
结果
我们报告称，与新冠疫情前的年份相比，疫情期间这两种生物标志物的监测都显著减少，无论是每年进行≥1次检测的患者比例，还是每位患者的平均检测次数。
结论
这些结果证明了HIC数据在监测医疗服务提供方面的实时效用，并支持提供追赶服务的干预措施，以尽量减少疫情的影响。需要进一步调查以确定这些干扰是否会与慢性HBV不良结局发生率的增加相关。
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