荷兰乳糜泻儿童及其家庭成员的HLA - DR抗原和表型

HLA-DR antigens and phenotypes in Dutch coeliac children and their families.

作者信息

Mearin M L, Bouquet J, Mourad N, Schoorel E, Sinaasappel M, Biemond I, Schreuder G M, Peña A S, van Gelderen H H, van Rood J J

出版信息

Clin Genet. 1985 Jan;27(1):45-50. doi: 10.1111/j.1399-0004.1985.tb00182.x.

DOI:10.1111/j.1399-0004.1985.tb00182.x

PMID:3872185

Abstract

In a study on the HLA-DR antigens and phenotypes in a series of Dutch coeliac children and their first-degree relatives, the B-cell antigens of 36 unrelated coeliac children, 110 first-degree relatives of 33 of them, and 201 controls were typed with the two-colour fluorescence test. The most frequent antigen was HLA-DR3 (69%), followed by DR7 (36%). The distribution of DR phenotypes showed that the most frequent was DR3/other DR (25%), followed by DR3/DR7 (17%), DR3/DR4 (14%), and DR3/DR3 (14%). However, due to the frequency of certain antigens in the controls, only phenotypes DR3/DR3 (relative risk = 6.2), DR3/DR7 (relative risk = 6.4), and DR3/DR4 (relative risk = 6.2) were significantly associated with CD. The family study confirmed the segregation of the disease with phenotypes DR3/DR3 and DR3/DR7. The present results show that the association between CD and phenotypes DR3/DR3 and DR3/DR7 is not an exclusive characteristic of Southern coeliac children.

摘要

在一项针对一系列荷兰乳糜泻儿童及其一级亲属的HLA - DR抗原和表型的研究中，采用双色荧光试验对36名无亲缘关系的乳糜泻儿童、其中33名儿童的110名一级亲属以及201名对照的B细胞抗原进行分型。最常见的抗原是HLA - DR3（69%），其次是DR7（36%）。DR表型的分布显示，最常见的是DR3/其他DR（25%），其次是DR3/DR7（17%）、DR3/DR4（14%）和DR3/DR3（14%）。然而，由于对照中某些抗原的频率，只有DR3/DR3（相对风险 = 6.2）、DR3/DR7（相对风险 = 6.4）和DR3/DR4（相对风险 = 6.2）表型与乳糜泻显著相关。家系研究证实了疾病与DR3/DR3和DR3/DR7表型的分离。目前的结果表明，乳糜泻与DR3/DR3和DR3/DR7表型之间的关联并非是南方乳糜泻儿童所特有的特征。