乳糜泻中的HLA-DR分型：遗传异质性的证据。
HLA-DR typing in coeliac disease: evidence for genetic heterogeneity.
作者信息
Ellis A, Taylor C J, Dillon-Remmy M, Woodrow J C, McConnell R B
出版信息
Br Med J (Clin Res Ed). 1984 Dec 8;289(6458):1571-3. doi: 10.1136/bmj.289.6458.1571.
Sixty nine propositi from a family study of coeliac disease were typed for HLA-DR antigens. Sixty three (91%) were found to carry the antigen DR3, which was a significantly greater proportion (p = 9.6 X 10(-24] than among the 168 controls (26%). Concurrently 42 children with the disease were DR typed. Not only was the frequency of DR3 significantly increased in these patients (86% versus 26% in controls; p = 3.1 X 10(-12] but so also was the frequency of DR7 (patients 60%, controls 29%; p = 5.8 X 10(-4]. When those propositi whose coeliac disease presented before the age of 20 were combined with the childhood coeliac group and a comparison made between these patients and the remainder of the propositi, all of whom presented when they were older than 20, the childhood onset group had a significant excess of DR7 (p = 2.2 X 10(-3] and a significant deficiency of DR2 (p = 3.5 X 10(-3]. These findings indicate that childhood coeliac disease and adult coeliac disease are genetically heterogeneous.
对来自乳糜泻家族研究的69名先证者进行了HLA - DR抗原分型。发现其中63名（91%）携带DR3抗原，这一比例显著高于168名对照者中的比例（26%，p = 9.6×10⁻²⁴）。同时，对42名患有该病的儿童进行了DR分型。这些患者中DR3的频率不仅显著增加（患者为86%，对照者为26%；p = 3.1×10⁻¹²），DR7的频率也显著增加（患者为60%，对照者为29%；p = 5.8×10⁻⁴）。当将20岁之前出现乳糜泻的先证者与儿童乳糜泻组合并，并将这些患者与其余所有在20岁以后出现症状的先证者进行比较时，儿童起病组的DR7显著过多（p = 2.2×10⁻³），而DR2显著缺乏（p = 3.5×10⁻³）。这些发现表明儿童乳糜泻和成人乳糜泻在遗传上是异质性的。
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