Strange Charlie, Make Barry J, Trudo Frank J, Harding Gale, Rodriguez Danielle, Eudicone James M, Feigler Norbert, Gandhi Hitesh N
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina, United States.
Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado, United States.
Chronic Obstr Pulm Dis. 2024 May 7;11(4):359-68. doi: 10.15326/jcopdf.2023.0485.
Patient perception of medication onset of effect is important for adherence. Although the Onset of Effect Questionnaire (OEQ) has been validated in patients with asthma, it has not been evaluated in patients with chronic obstructive pulmonary disease (COPD). This study evaluated the COPD-OEQ in patients with COPD.
Two analyses (qualitative and quantitative) were conducted to assess the content validity and psychometric properties of the COPD-OEQ in participants with COPD. In the qualitative analysis, interviews assessed content validity by concept elicitation (CE) and cognitive interviewing (CI). CE included questions to understand patient experience related to onset of medication effect. CI included completion of the COPD-OEQ and assessment of the COPD-OEQ items, response options, and instructions. During the 2-week quantitative analysis, 2 versions of the COPD-OEQ (Weekly and Daily) were administered to assess test-retest reliability, construct validity, and known-groups validity.
The qualitative analysis demonstrated that 3 of the 5 COPD-OEQ items were relevant and understood as intended. Qualitative findings demonstrated inconsistent evidence that the COPD-OEQ Weekly and Daily were reliable and valid measures in participants with COPD. Test-retest reliability was observed for the COPD-OEQ Weekly and Daily; however, construct validitywas weak and demonstrated inconsistent correlations among COPD-OEQ items. Overall, known-groups validity was not demonstrated.
The weak evidence from the quantitative analysis of the COPD-OEQ Weekly and Daily tools does not support use of the OEQ in general COPD. The study supports the content validity for the assessment of perceived onset of effect in patients with COPD.
患者对药物起效的认知对于坚持用药很重要。尽管起效问卷（OEQ）已在哮喘患者中得到验证，但尚未在慢性阻塞性肺疾病（COPD）患者中进行评估。本研究对COPD患者的慢性阻塞性肺疾病起效问卷（COPD - OEQ）进行了评估。
进行了两项分析（定性和定量），以评估COPD - OEQ在COPD参与者中的内容效度和心理测量特性。在定性分析中，通过概念激发（CE）和认知访谈（CI）评估内容效度。CE包括一些问题，以了解患者与药物起效相关的经历。CI包括完成COPD - OEQ以及评估COPD - OEQ的项目、回答选项和说明。在为期2周的定量分析中，使用了两个版本的COPD - OEQ（每周版和每日版）来评估重测信度、结构效度和已知组效度。
定性分析表明，COPD - OEQ的5个项目中有3个相关且按预期被理解。定性研究结果表明，关于COPD - OEQ每周版和每日版在COPD参与者中是可靠且有效的测量工具的证据并不一致。观察到COPD - OEQ每周版和每日版的重测信度；然而，结构效度较弱，且COPD - OEQ项目之间的相关性不一致。总体而言，未证明已知组效度。
对COPD - OEQ每周版和每日版工具的定量分析证据不足，不支持在一般COPD患者中使用OEQ。该研究支持了评估COPD患者感知起效的内容效度。
