Sirisuthivoranunt Surachet, Wongdama Supisara, Phumariyapong Phumithep, Nokdhes Ya-Nin, Thongjaroensirikul Panwadee, Techapichetvanich Thanya, Pettersson Mattias, Ågren Martin, Wanitphakdeedecha Rungsima
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok, 10700, Thailand.
Department of Odontology, Faculty of Medicine, Umeå University, Umeå, Sweden.
Dermatol Ther (Heidelb). 2024 May;14(5):1315-1325. doi: 10.1007/s13555-024-01177-1. Epub 2024 May 9.
Botulinum toxin serotype A (BoNT/A) is widely used for minimal invasive aesthetic treatments. Different brands of BoNT/A exhibit structural variations. The aim of this study was to compare the duration and efficacy of various BoNT/A brands available in Thailand for reducing bite force and treating wrinkles.
Fifty participants were randomly assigned to one of five groups, with each group receiving a different BoNT/A brand, namely, incobotulinumtoxinA (IncoA), onabotulinumtoxinA (OnaA), abobotulinumtoxinA (AboA), letibotulinumtoxinA (LetiA), and prabotulinumtoxinA (PraboA). BoNT/A was administered to the masseter muscle and the upper face. Bite force was measured before injection and at 2, 4, 8, 12, 16, 20, and 24 weeks post-injection. Evaluation scores for wrinkle improvement were assessed after the treatment.
The most significant reduction in bite force occurred between 2 and 4 weeks post-injection. PraboA demonstrated the most substantial reduction in bite force, while IncoA had the least effect. However, the percentage of bite force reduction did not exhibit statistical significance between BoNT/A types. Additionally, the reduction in bite force for all BoNT/A types was reversed at 4 months post-injection. More than half of the participants experienced improvement beyond 16 weeks.
The structural differences among BoNT/A brands did not significantly affect the longevity and efficacy of bite force reduction and wrinkle treatment.
ClinicalTrials.gov identifier: TCTR20211205001 (registered 4 Dec 2021).
A型肉毒毒素（BoNT/A）广泛用于微创美容治疗。不同品牌的BoNT/A存在结构差异。本研究旨在比较泰国市场上各种BoNT/A品牌在降低咬合力和治疗皱纹方面的持续时间和疗效。
50名参与者被随机分配到五组中的一组，每组接受不同品牌的BoNT/A，即incobotulinumtoxinA（IncoA）、onabotulinumtoxinA（OnaA）、abobotulinumtoxinA（AboA）、letibotulinumtoxinA（LetiA）和prabotulinumtoxinA（PraboA）。将BoNT/A注射到咬肌和上脸。在注射前以及注射后2、4、8、12、16、20和24周测量咬合力。治疗后评估皱纹改善的评分。
咬合力在注射后2至4周下降最为显著。PraboA在咬合力下降方面最为显著，而IncoA的效果最小。然而，不同类型BoNT/A之间咬合力下降的百分比没有统计学意义。此外，所有类型BoNT/A的咬合力下降在注射后4个月时逆转。超过一半的参与者在16周后仍有改善。
BoNT/A品牌之间的结构差异对降低咬合力和治疗皱纹的持续时间和疗效没有显著影响。
ClinicalTrials.gov标识符：TCTR20211205001（2021年12月4日注册）。
