Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
BMC Pulm Med. 2024 May 9;24(1):225. doi: 10.1186/s12890-024-03045-2.
To explore the potential association between dietary live microbes and the prevalence of Chronic Obstructive Pulmonary Diseases (COPD).
In this cross-sectional study, data of 9791 participants aged 20 years or older in this study were collected from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2018. Participants in this study were classified into three groups according to the Sanders' dietary live microbe classification system: low, medium, and high dietary live microbe groups. COPD was defined by a combination of self-reported physician diagnoses and standardized medical status questionnaires. Logistic regression and subgroup analysis were used to assess whether dietary live microbes were associated with the risk of COPD.
Through full adjustment for confounders, participants in the high dietary live microbe group had a low prevalence of COPD in contrast to those in low dietary live microbe group (OR: 0.614, 95% CI: 0.474-0.795, and p < 0.001), but no significant association with COPD was detected in the medium and the low dietary live microbe groups. This inverse relationship between dietary live microbe intake and COPD prevalence was more inclined to occur in smokers, females, participants aged from 40 to 59 years old and non-obese participants.
A high dietary live microbe intake was associated with a low prevalence of COPD, and this negative correlation was detected especially in smokers, females, participants aged from 40 to 59 years old and non-obese participants.
探讨饮食中活菌与慢性阻塞性肺疾病（COPD）患病率之间的潜在关联。
在这项横断面研究中，我们收集了 2013 年至 2018 年间国家健康和营养调查（NHANES）中 9791 名 20 岁或 20 岁以上参与者的数据。根据 Sanders 的饮食活菌分类系统，将参与者分为三组：低、中、高饮食活菌组。COPD 由自我报告的医生诊断和标准化的医学状况问卷相结合定义。使用逻辑回归和亚组分析来评估饮食活菌是否与 COPD 风险相关。
通过充分调整混杂因素，与低饮食活菌组相比，高饮食活菌组的 COPD 患病率较低（OR：0.614，95%CI：0.474-0.795，p<0.001），但中、低饮食活菌组与 COPD 无显著相关性。饮食活菌摄入与 COPD 患病率之间的这种反比关系在吸烟者、女性、40 至 59 岁的参与者和非肥胖参与者中更为明显。
高饮食活菌摄入与 COPD 患病率较低相关，这种负相关在吸烟者、女性、40 至 59 岁的参与者和非肥胖参与者中更为明显。
