Department of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, PR China.
Medical Department, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, PR China.
Heart Lung. 2024 Sep-Oct;67:108-113. doi: 10.1016/j.hrtlng.2024.05.006. Epub 2024 May 14.
Anthocyanins have anti-inflammatory and antioxidant properties. Several studies have demonstrated that anthocyanins are associated with many chronic diseases, but few studies have focused on the relationship between anthocyanins and chronic obstructive pulmonary disease (COPD).
This survey aimed to explore the relationship between dietary anthocyanin intake and COPD in US adults over the age of 40.
A cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 was conducted. We used univariate and multivariate logistic regression and restricted cubic spline (RCS) to analyze the relationship between dietary anthocyanins and COPD. Subgroup and interaction analyses were adopted to assess whether there were differences in the relationship between dietary anthocyanin intake and COPD in different groups.
A total of 2862 participants aged ≥ 40 years were analyzed, of whom 213 were diagnosed with COPD. The highest tertile of dietary anthocyanin intake was negatively correlated with COPD compared to the lowest after adjusting potential confounders (Model 1, OR = 0.414; 95% CI: (0.245, 0.699), P-trend = 0.002; Model 2, OR = 0.363; 95% CI: (0.210, 0.627), P-trend = 0.002; Model 3, OR = 0.614; 95% CI: (0.383, 0.985), P-trend = 0.040). The RCS curve showed a significant inverse linear relationship between dietary anthocyanin intake and COPD (P non-linear = 0.734). In subgroup analyses, the negative correlation between dietary anthocyanin intake and COPD existed across different subgroups.
Our study indicated that higher dietary anthocyanins are a protective factor against the presence of COPD in the US aged over 40.
花色苷具有抗炎和抗氧化作用。多项研究表明，花色苷与许多慢性疾病有关，但很少有研究关注花色苷与慢性阻塞性肺疾病（COPD）之间的关系。
本调查旨在探讨美国 40 岁以上成年人饮食花色苷摄入量与 COPD 之间的关系。
采用 2017-2018 年全国健康与营养调查（NHANES）的横断面研究。我们使用单变量和多变量逻辑回归以及限制立方样条（RCS）分析饮食花色苷与 COPD 之间的关系。采用亚组和交互作用分析来评估不同组之间饮食花色苷摄入量与 COPD 之间的关系是否存在差异。
共分析了 2862 名年龄≥40 岁的参与者，其中 213 人被诊断为 COPD。在调整了潜在混杂因素后，与最低摄入量 tertile 相比，饮食花色苷摄入量最高 tertile 与 COPD 呈负相关（模型 1，OR=0.414；95%CI：（0.245，0.699），P 趋势=0.002；模型 2，OR=0.363；95%CI：（0.210，0.627），P 趋势=0.002；模型 3，OR=0.614；95%CI：（0.383，0.985），P 趋势=0.040）。RCS 曲线显示饮食花色苷摄入量与 COPD 之间呈显著负线性关系（P 非线性=0.734）。在亚组分析中，饮食花色苷摄入量与 COPD 之间的负相关性存在于不同的亚组中。
我们的研究表明，较高的饮食花色苷摄入量是美国 40 岁以上人群 COPD 发生的保护因素。
