Department of Endocrinology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, 22 Guangrong Road, Gulou District, Fuzhou City, Fujian, China.
Arch Osteoporos. 2024 Aug 3;19(1):69. doi: 10.1007/s11657-024-01429-9.
The association between live microbe intake and osteoporosis in postmenopausal women remains unknown. The research findings indicated that an increased intake of live microbes through dietary sources was associated with a low prevalence of osteoporosis among postmenopausal women.
To investigate the relationship between the consumption of live microbes in the diet and osteoporosis in postmenopausal women.
A cross-sectional investigation using data obtained from the National Health and Nutrition Examination Survey was conducted. Participants were classified into three groups by using the dietary live microbe classification system developed by Sanders. Dual x-ray absorptiometry was used to measure body mineral density, and osteoporosis was diagnosed according to the World Health Organization criteria. We conducted a crude and adjusted multivariate logistic regression analysis, and utilized the restricted cubic splines model to assess the correlation between the consumption of live microbes in the diet and osteoporosis in postmenopausal women.
A total of 1378 women who had undergone menopause were enrolled in the study. After controlling for potential covariates, individuals with a high consumption of live microbes in their diet exhibited a notably low prevalence of osteoporosis in comparison to those with a low intake of dietary live microbes (odd ratio: 0.46, 95% confidence interval: 0.23, 0.93, P = 0.03). Subgroup analysis showed the stability of the results, and restricted cubic splines showed an approximate L-shape curve.
In this research, a higher consumption of live microbes in the diet was linked to a low prevalence of osteoporosis in postmenopausal women.
绝经后妇女肠道内活菌摄入与骨质疏松症的关联尚不清楚。研究结果表明，通过饮食摄入更多的活菌与绝经后妇女骨质疏松症的低患病率有关。
研究饮食中活菌的摄入与绝经后妇女骨质疏松症之间的关系。
采用横断面调查，利用国家健康与营养调查的数据。采用桑德斯开发的饮食活菌分类系统将参与者分为三组。采用双能 X 线吸收法测量身体矿物质密度，根据世界卫生组织标准诊断骨质疏松症。我们进行了未经调整和调整后的多变量逻辑回归分析，并利用限制立方样条模型评估饮食中活菌摄入与绝经后妇女骨质疏松症之间的相关性。
共纳入 1378 名绝经后女性。在控制了潜在的混杂因素后，与低饮食活菌摄入者相比，高饮食活菌摄入者骨质疏松症的患病率明显较低（比值比：0.46，95%置信区间：0.23，0.93，P=0.03）。亚组分析显示结果稳定，限制立方样条显示近似 L 形曲线。
本研究表明，饮食中摄入更多的活菌与绝经后妇女骨质疏松症的低患病率有关。
