Hausen B M
Dtsch Med Wochenschr. 1985 Apr 19;110(16):634-8. doi: 10.1055/s-2008-1068877.
Self-medication of rheumatic complaints in the upper arm, by one woman, and of a lipoma on the thigh, by another, with pure laurel oil caused within two weeks severe contact dermatitis and swellings far from the point of application. Sesquiterpene lactone, contained within laurel oil, proved to be the cause of the induced contact allergy. Since the acquired specific hypersensitivity of the eczema type is directed primarily against the alpha-methylene group of the lactone, cross-reactions were observed against a large number of other plans which are botanically unrelated but contain substances of a similar class. Those allergic to laurel oil should therefore avoid many cosmetics, articles of hygiene, foods, drinks and medicinal preparations which contain herbs, as well as gardening, certain cut flowers and perfumes, especially those of the family Compositae. The present trend "back to nature" makes further sensitizations against laurel oil likely. This would seem to justify the inclusion of these substances among the group of potentially harmful environmental and occupational products.
一名女性用纯月桂油自行治疗上臂的风湿性疾病，另一名女性用其自行治疗大腿上的脂肪瘤，两周内引发了严重的接触性皮炎，且在远离涂抹部位处出现肿胀。月桂油中含有的倍半萜内酯被证实是引发接触性过敏的原因。由于湿疹型获得性特异性超敏反应主要针对内酯的α-亚甲基基团，因此观察到对大量其他植物产生交叉反应，这些植物在植物学上并无关联，但含有类似种类的物质。因此，对月桂油过敏的人应避免许多含有草药的化妆品、卫生用品、食品、饮料和药物制剂，以及园艺活动、某些切花和香水，尤其是菊科的那些。当前“回归自然”的趋势可能会使对月桂油的进一步致敏情况增多。这似乎证明将这些物质列入潜在有害的环境和职业产品类别是合理的。
