降钙素原、白三烯 B4、血清淀粉样蛋白 A 和 C 反应蛋白在不同类型肺炎患儿中的表达及意义：一项观察性研究。
Expression and significance of procalcitonin, leukotriene B4, serum amyloid A, and C-reactive protein in children with different types of pneumonia: An observational study.
机构信息
Department of Paediatrics, The Fifth People's Hospital of Zhuhai, Zhuhai, Guangdong, China.
Department of Human Anatomy and Histology & Embryology, Zunyi Medical University, Zhuhai Campus, Zhuhai, Guangdong, China.
出版信息
Medicine (Baltimore). 2024 May 10;103(19):e37817. doi: 10.1097/MD.0000000000037817.
This study aimed to investigate the expression and significance of serum procalcitonin (PCT), leukotriene B4 (LTB4), Serum amyloid A (SAA), and C-reactive protein (CRP) in children with different types of pneumonia caused by different pathogenic infections. One hundred and one children with pneumonia admitted to The Fifth People Hospital of Zhuhai from July 2019 to June 2020 were enrolled and divided into 38 cases in the bacterial group, 30 cases in the mycoplasma group, and 33 cases in the virus group according to the different types of pathogens. The patients were divided into 42 cases in the noncritical group, 33 cases in the critical group, and 26 cases in the very critical group according to the pediatric clinical illness score (PCIS), and 30 healthy children were selected as the control group during the same period. Comparison of serum PCT, SAA: bacterial group > mycoplasma group > viral group > control group with significant differences (P < .05). Receiver operator characteristic (ROC) analysis showed that the area under the curves (AUCs) of serum PCT, LTB4, SAA, and CRP for the diagnosis of bacterial pneumonia were 1.000, 0.531, 0.969, and 0.833, respectively, and the AUCs for the diagnosis of mycoplasma pneumonia were 0.653, 0.609, 0.547, and 0.652, respectively, and the AUCs for the diagnosis of viral pneumonia were 0.888, 0.570, 0.955, and 1.000, respectively. Comparison of serum PCT, LTB4, SAA: very critical group > critical group > noncritical group > control group, with significant differences (P < .05). Serum PCT, LTB4, and SAA were negatively correlated with PCIS score by Pearson analysis (P < .05). Serum PCT and SAA showed diagnostic value for bacterial pneumonia, and serum SAA and CRP showed diagnostic value for viral pneumonia; serum PCT, LTB4, and SAA correlate with severity of disease and show higher expression with worsening of the condition.
本研究旨在探讨不同病原体感染引起的儿童不同类型肺炎患者血清降钙素原（PCT）、白三烯 B4（LTB4）、血清淀粉样蛋白 A（SAA）和 C 反应蛋白（CRP）的表达及意义。选择 2019 年 7 月至 2020 年 6 月珠海市第五人民医院收治的肺炎患儿 101 例，根据病原体类型分为细菌组 38 例、支原体组 30 例、病毒组 33 例。根据儿童临床疾病评分（PCIS）将患儿分为非危重组 42 例、危重组 33 例、极危重组 26 例，同期选择 30 例健康儿童作为对照组。比较血清 PCT、SAA：细菌组>支原体组>病毒组>对照组，差异有统计学意义（P<0.05）。受试者工作特征（ROC）曲线分析显示，血清 PCT、LTB4、SAA、CRP 对细菌性肺炎的诊断 AUC 分别为 1.000、0.531、0.969、0.833，对支原体肺炎的诊断 AUC 分别为 0.653、0.609、0.547、0.652，对病毒性肺炎的诊断 AUC 分别为 0.888、0.570、0.955、1.000。比较血清 PCT、LTB4、SAA：极危重组>危重组>非危重组>对照组，差异有统计学意义（P<0.05）。Pearson 分析结果显示，血清 PCT、LTB4、SAA 与 PCIS 评分呈负相关（P<0.05）。血清 PCT、SAA 对细菌性肺炎有诊断价值，血清 SAA、CRP 对病毒性肺炎有诊断价值；血清 PCT、LTB4、SAA 与疾病严重程度相关，病情加重时表达水平升高。
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