College of Computer and Information, Hohai University, Nanjing, 211100, PR China.
College of information Science and Technology & College of Artificial Intelligence, Nanjing Forestry University, Nanjing 210037, PR China.
Comput Methods Programs Biomed. 2024 Jun;251:108199. doi: 10.1016/j.cmpb.2024.108199. Epub 2024 Apr 30.
In cervical cell diagnostics, autonomous screening technology constitutes the foundation of automated diagnostic systems. Currently, numerous deep learning-based classification techniques have been successfully implemented in the analysis of cervical cell images, yielding favorable outcomes. Nevertheless, efficient discrimination of cervical cells continues to be challenging due to large intra-class and small inter-class variations. The key to dealing with this problem is to capture localized informative differences from cervical cell images and to represent discriminative features efficiently. Existing methods neglect the importance of global morphological information, resulting in inadequate feature representation capability.
To address this limitation, we propose a novel cervical cell classification model that focuses on purified fusion information. Specifically, we first integrate the detailed texture information and morphological structure features, named cervical pathology information fusion. Second, in order to enhance the discrimination of cervical cell features and address the data redundancy and bias inherent after fusion, we design a cervical purification bottleneck module. This model strikes a balance between leveraging purified features and facilitating high-efficiency discrimination. Furthermore, we intend to unveil a more intricate cervical cell dataset: Cervical Cytopathology Image Dataset (CCID).
Extensive experiments on two real-world datasets show that our proposed model outperforms state-of-the-art cervical cell classification models.
The results show that our method can well help pathologists to accurately evaluate cervical smears.
在宫颈细胞诊断中,自主筛查技术是自动化诊断系统的基础。目前,许多基于深度学习的分类技术已成功应用于宫颈细胞图像分析,取得了良好的效果。然而,由于宫颈细胞的类内变异性大、类间变异性小,因此对其进行有效区分仍然具有挑战性。解决这个问题的关键是从宫颈细胞图像中捕捉局部的有意义的差异,并有效地表示判别特征。现有的方法忽略了全局形态信息的重要性,导致特征表示能力不足。
为了解决这个局限性,我们提出了一种新的专注于纯化融合信息的宫颈细胞分类模型。具体来说,我们首先整合详细的纹理信息和形态结构特征,命名为宫颈病理信息融合。其次,为了增强宫颈细胞特征的辨别能力,并解决融合后数据的冗余和偏差问题,我们设计了一个宫颈净化瓶颈模块。该模型在利用纯化特征和促进高效区分之间取得了平衡。此外,我们旨在揭示一个更复杂的宫颈细胞数据集:宫颈细胞学图像数据集(CCID)。
在两个真实数据集上的广泛实验表明,我们提出的模型优于最先进的宫颈细胞分类模型。
结果表明,我们的方法可以帮助病理学家准确评估宫颈涂片。