Konenkov V I, Koroleva E G, Orlov N B, Prokof'ev V F, Shevchenko A V, Novikov A M, Dergacheva T I
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2018 Sep;165(5):698-701. doi: 10.1007/s10517-018-4245-0. Epub 2018 Sep 17.
We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.
我们分析了子宫肌瘤患者血清中的细胞因子谱，发现IFNγ水平显著降低，IL-1β和TNFα水平有下降趋势；IL-6、IL-8和IL-12p70水平与健康女性无差异。组织中负责炎症和血管生成的因子浓度下降不利于子宫组织的增殖和分化。
