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J Ovarian Res. 2017 Jul 12;10(1):43. doi: 10.1186/s13048-017-0341-4.
2
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts.男性不育的原因:一项针对1737例精子总数减少患者的9年前瞻性单中心研究。
Hum Reprod. 2017 Jan;32(1):18-31. doi: 10.1093/humrep/dew284. Epub 2016 Nov 17.
3
Impact of female age and nulligravidity on fecundity in an older reproductive age cohort.高龄生育年龄队列中女性年龄及未孕对生育力的影响。
Fertil Steril. 2016 Jun;105(6):1584-1588.e1. doi: 10.1016/j.fertnstert.2016.02.028. Epub 2016 Mar 5.
4
An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan.对哈马丹法特米耶医院不孕不育中心转诊患者不孕原因的流行病学调查。
Iran J Reprod Med. 2015 Aug;13(8):513-6.
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Incidence of infertility and risk factors of impaired fecundity among newly married couples in a Chinese population.中国人群中新婚夫妇的不孕发生率及生育力受损的危险因素。
Reprod Biomed Online. 2015 Jan;30(1):92-100. doi: 10.1016/j.rbmo.2014.10.002. Epub 2014 Oct 13.
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Infertility in Mazandaran province - north of Iran: an etiological study.伊朗北部马赞德兰省的不孕症:一项病因学研究。
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Infertility among couples in a population-based study in Iran: prevalence and associated risk factors.伊朗一项基于人群的研究中夫妻的不孕症:患病率及相关危险因素
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摩洛哥人群中的不孕症:拉巴特生殖健康中心的一项病因学研究。

Infertility in the Moroccan population: an etiological study in the reproductive health centre in Rabat.

作者信息

Benbella Amal, Aboulmakarim Siham, Hardizi Houyam, Zaidouni Asmaa, Bezad Rachid

机构信息

Assisted Reproductive Technology Unit of the Reproductive Health Centre, University Hospital Ibn Sina, Rabat, Morocco.

Laboratory of Medical Biotechnology (Med Biotech), Faculty of Medicine and Pharmacy, University Mohamed V, Rabat, Morocco.

出版信息

Pan Afr Med J. 2018 Jul 10;30:204. doi: 10.11604/pamj.2018.30.204.13498. eCollection 2018.

DOI:10.11604/pamj.2018.30.204.13498
PMID:30574223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6294973/
Abstract

The causes of infertility vary widely and differ between regions and within countries. There is no report on this subject in Morocco. Therefore, the aim of this study was to determine the causes of infertility in Moroccan infertile couples and to compare the findings with data from the various published studies. This retrospective study included 1265 infertile couples who attended the Assisted Reproductive Technology Unit of the Reproductive Health Centre of the University Hospital Ibn Sina in Rabat. All couples had been infertile for at least 1 year and both partners were fully investigated. The median duration of infertility was 5 ± 4 years. Couples had primary and secondary infertility in 77.2% and 22.8% of cases, respectively. Among the 1265 couples, 39.6% had a female factor, 28.2% had a male factor, 17% had both male and female factors and in 15.2% of couples, the cause of infertility was undetermined. The most common causes of male infertility were varicocele (14.3%), obstructive azoospermia (7%), Congenital anomalies (5.5%) and male accessory gland infection (4%). Results showed that 54.8% of men had a normal semen analysis. Among women, infertility factors were ovulatory disorders (27.5%), tubal factor (26.6%), uterine factor (12.6%), endometriosis (4.1%), and 43.4% of women were normal. The causes of infertility in this study are comparable with those reported by the World Health Organization and other studies. However, the substantial delay before attending an infertility clinic highlighted by the study needs additional consideration.

摘要

不孕不育的原因多种多样,因地区和国家内部而异。摩洛哥尚无关于该主题的报告。因此,本研究的目的是确定摩洛哥不孕不育夫妇的不孕原因,并将研究结果与各项已发表研究的数据进行比较。这项回顾性研究纳入了1265对不孕不育夫妇,他们前往拉巴特伊本·西那大学医院生殖健康中心的辅助生殖技术科就诊。所有夫妇均不孕至少1年,且双方均接受了全面检查。不孕的中位持续时间为5±4年。夫妇中,原发性不孕和继发性不孕分别占77.2%和22.8%。在这1265对夫妇中,39.6%存在女性因素,28.2%存在男性因素,17%男女双方均有因素,15.2%的夫妇不孕原因不明。男性不育最常见的原因是精索静脉曲张(14.3%)、梗阻性无精子症(7%)、先天性异常(5.5%)和男性附属腺感染(4%)。结果显示,54.8%的男性精液分析正常。在女性中,不孕因素包括排卵障碍(27.5%)、输卵管因素(26.6%)、子宫因素(12.6%)、子宫内膜异位症(4.1%),43.4%的女性正常。本研究中不孕不育的原因与世界卫生组织及其他研究报告的原因相当。然而,该研究强调的就诊不孕不育诊所前的显著延迟需要进一步考虑。