Zhou Chenguang, Cheng Oumei
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Aging Neurosci. 2025 Feb 18;17:1510411. doi: 10.3389/fnagi.2025.1510411. eCollection 2025.
Parkinson's disease (PD) is a progressive neurodegenerative disorder with increasing global prevalence. This study investigated the association between the American Heart Association's Life's Essential 8 (LE8) and PD prevalence using a large, nationally representative database.
We analyzed data from 18,277 participants aged 40 years and older from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. LE8 scores were calculated based on diet, physical activity, nicotine exposure, sleep, body mass index, blood lipids, blood glucose, and blood pressure. PD cases were identified through self-reported anti-PD medication use. Multivariate logistic regression models were employed to examine the association between LE8 and PD prevalence, adjusting for various demographic and clinical factors. In addition, we performed restricted cubic splines (RCS), subgroup analyses, and weighted quantile sum (WQS) regression to verify the robustness of the study results.
The prevalence of PD was 1.3% in the study population. After full adjustment, individuals with moderate (50-79) and high (80-100) LE8 scores showed lower odds of PD compared to those with low (0-49) scores (OR 0.53, 95% CI 0.29-0.97 and OR 0.43, 95% CI 0.17-1.04, respectively; for trend <0.05). A dose-response relationship was observed between LE8 scores and PD prevalence. WQS regression identified dietary factors and glycemic health as the main contributors to the inverse association between LE8 and PD.
Our findings suggest a significant inverse association between Life's Essential 8 (LE8) and PD prevalence, with dietary factors and glycemic health emerging as the most influential components.
帕金森病（PD）是一种全球患病率不断上升的进行性神经退行性疾病。本研究使用一个大型的、具有全国代表性的数据库，调查了美国心脏协会的生命八大要素（LE8）与PD患病率之间的关联。
我们分析了2005 - 2018年国家健康与营养检查调查（NHANES）中18277名40岁及以上参与者的数据。LE8分数基于饮食、身体活动、尼古丁暴露、睡眠、体重指数、血脂、血糖和血压进行计算。通过自我报告的抗PD药物使用情况来确定PD病例。采用多变量逻辑回归模型来检验LE8与PD患病率之间的关联，并对各种人口统计学和临床因素进行了调整。此外，我们还进行了受限立方样条（RCS）分析、亚组分析和加权分位数和（WQS）回归，以验证研究结果的稳健性。
研究人群中PD的患病率为1.3%。经过全面调整后，与低（0 - 49）分者相比，中等（50 - 79）和高（80 - 100）LE8分数的个体患PD的几率较低（OR分别为0.53，95%CI 0.29 - 0.97和OR 0.43，95%CI 0.17 - 1.04；趋势<0.05）。在LE8分数与PD患病率之间观察到剂量反应关系。WQS回归确定饮食因素和血糖健康是LE8与PD之间负相关的主要贡献因素。
我们的研究结果表明，生命八大要素（LE8）与PD患病率之间存在显著的负相关，饮食因素和血糖健康是最具影响力的组成部分。
