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网络荟萃分析不同运动措施对癌症患者肌少症干预效果的影响。

Network meta-analysis of the intervention effects of different exercise measures on Sarcopenia in cancer patients.

机构信息

Department of Special Medical Care, Cancer Hospital, Chinese Academy of Medical Sciences, Chaoyang district, 100021, Beijing, China.

出版信息

BMC Public Health. 2024 May 10;24(1):1281. doi: 10.1186/s12889-024-18493-y.

DOI:10.1186/s12889-024-18493-y
PMID:38730397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11083843/
Abstract

PURPOSE

This study aims to investigate the impact of four exercise modes (aerobic exercise, resistance exercise, aerobic combined with resistance multimodal exercise, and stretching) on the physical performance of cancer patients.

METHODS

Randomized controlled trials (RCTs) were exclusively collected from PubMed, EMBASE, Web of Science, and The Cochrane Library, with a search deadline of April 30, 2023. Different exercise interventions on the physical performance of cancer patients were studied, and the Cochrane risk of bias assessment tool was employed to evaluate the quality of the included literature. Data analysis was conducted using STATA 15.1 software.

RESULTS

This study included ten randomized controlled trials with a combined sample size of 503 participants. Network meta-analysis results revealed that aerobic combined with resistance multimodal exercise could reduce fat mass in cancer patients (SUCRA: 92.3%). Resistance exercise could improve lean mass in cancer patients (SUCRA: 95.7%). Furthermore, resistance exercise could enhance leg extension functionality in cancer patients with sarcopenia (SUCRA: 83.0%).

CONCLUSION

This study suggests that resistance exercise may be more beneficial for cancer-related sarcopenia.In clinical practice, exercise interventions should be tailored to the individual patients' circumstances.

REGISTRATION NUMBER

This review was registered on INPLASY2023110025; DOI number is https://doi.org/10.37766/inplasy2023.11.0025 .

摘要

目的

本研究旨在探讨四种运动模式（有氧运动、抗阻运动、有氧结合抗阻的多模态运动以及伸展运动）对癌症患者身体机能的影响。

方法

本研究仅从 PubMed、EMBASE、Web of Science 和 The Cochrane Library 中收集了随机对照试验（RCT），检索截止日期为 2023 年 4 月 30 日。研究了不同的运动干预对癌症患者身体机能的影响，并采用 Cochrane 偏倚风险评估工具评估纳入文献的质量。使用 STATA 15.1 软件进行数据分析。

结果

本研究纳入了 10 项随机对照试验，共有 503 名参与者。网络荟萃分析结果表明，有氧结合抗阻的多模态运动可以减少癌症患者的脂肪量（SUCRA：92.3%）。抗阻运动可以增加癌症患者的瘦体重（SUCRA：95.7%）。此外，抗阻运动可以提高患有肌少症的癌症患者的腿部伸展功能（SUCRA：83.0%）。

结论

本研究表明，抗阻运动可能对癌症相关的肌少症更有益。在临床实践中，应根据患者的具体情况选择运动干预措施。

注册号

本综述在 INPLASY2023110025 进行了注册；DOI 号为 https://doi.org/10.37766/inplasy2023.11.0025 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/23e2cef1e024/12889_2024_18493_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/2756bbb0198d/12889_2024_18493_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/a6b402fd7998/12889_2024_18493_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/5e2f7efedbe3/12889_2024_18493_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/87a9fc7917de/12889_2024_18493_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/dff511fcef45/12889_2024_18493_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/23e2cef1e024/12889_2024_18493_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/2756bbb0198d/12889_2024_18493_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/a6b402fd7998/12889_2024_18493_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/5e2f7efedbe3/12889_2024_18493_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/87a9fc7917de/12889_2024_18493_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/dff511fcef45/12889_2024_18493_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9558/11083843/23e2cef1e024/12889_2024_18493_Fig6_HTML.jpg

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