Burkhanbayeva Tolkynay, Ukhov Arthur, Fedorishin Dmitry, Gubankov Alexander, Kurzina Irina, Bakibaev Abdigali, Yerkassov Rakhmetulla, Mashan Togzhan, Suyundikova Faiziya, Nurmukhanbetova Nurgul, Khamitova Aina
Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Faculty of Chemistry, National Research Tomsk State University, Arkady Ivanov St. 49, 634028 Tomsk, Russia.
Materials (Basel). 2024 Apr 26;17(9):2041. doi: 10.3390/ma17092041.
This study represents an advancement in the field of composite material engineering, focusing on the synthesis of composite materials derived from porous hydroxyapatite via surface modification employing cucurbit[n]urils, which are highly promising macrocyclic compounds. The surface modification procedure entailed the application of cucurbit[n]urils in an aqueous medium onto the hydroxyapatite surface. A comprehensive characterization of the resulting materials was undertaken, employing analytical techniques including infrared (IR) spectroscopy and scanning electron microscopy (SEM). Subsequently, the materials were subjected to rigorous evaluation for their hemolytic effect, anti-inflammatory properties, and cytotoxicity. Remarkably, the findings revealed a notable absence of typical hemolytic effects in materials incorporating surface-bound cucurbit[n]urils. This observation underscores the potential of these modified materials as biocompatible alternatives. Notably, this discovery presents a promising avenue for the fabrication of resilient and efficient biocomposites, offering a viable alternative to conventional approaches. Furthermore, these findings hint at the prospect of employing supramolecular strategies involving encapsulated cucurbit[n]urils in analogous processes. This suggests a novel direction for further research, potentially unlocking new frontiers in material engineering through the exploitation of supramolecular interactions.
本研究代表了复合材料工程领域的一项进展，重点是通过使用葫芦[n]脲（一类极具前景的大环化合物）进行表面改性，合成源自多孔羟基磷灰石的复合材料。表面改性过程包括在水介质中将葫芦[n]脲应用于羟基磷灰石表面。采用包括红外（IR）光谱和扫描电子显微镜（SEM）在内的分析技术，对所得材料进行了全面表征。随后，对这些材料的溶血作用、抗炎特性和细胞毒性进行了严格评估。值得注意的是，研究结果显示，在含有表面结合葫芦[n]脲的材料中，明显没有典型的溶血作用。这一观察结果突出了这些改性材料作为生物相容性替代品的潜力。值得注意的是，这一发现为制造有弹性且高效的生物复合材料提供了一条有前景的途径，为传统方法提供了可行替代方案。此外，这些发现暗示了在类似过程中采用涉及包封葫芦[n]脲的超分子策略的前景。这为进一步研究指明了一个新方向，有可能通过利用超分子相互作用在材料工程领域开辟新的前沿。
