State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Ethnopharmacol. 2022 Oct 28;297:115421. doi: 10.1016/j.jep.2022.115421. Epub 2022 Jun 2.
Essential oils (EO) are volatile compounds obtained from different parts of natural plants, and have been used in national, traditional and folk medicine to treat various health problems all over the world. Records indicate that in history, herbal medicines rich in EO have been widely used for the treatment of CVDs in many countries, such as China.
This review focused on the traditional application and modern pharmacological mechanisms of herbal medicine EO against CVDs in preclinical and clinical trials through multi-targets synergy. Besides, the EO and anti-CVDs drugs were compared, and the broad application of EO was explained from the properties of drugs and aromatic administration routes.
Information about EO and CVDs was collected from electronic databases such as Web of Science, ScienceDirect, PubMed, and China National Knowledge Infrastructure (CNKI). The obtained data sets were sequentially arranged for better understanding of EO' potential.
The study showed that EO had significant application in CVDs at different countries or regions since ancient times. Aiming at the complex pathological mechanisms of CVDs, including intracellular calcium overload, oxidative stress, inflammation, vascular endothelial cell injury and dysfunction and dyslipidemia, we summarized the roles of EO on CVDs in preclinical and clinical through multi-targets intervention. Besides, EO had the dual properties of drug and excipients. And aromatherapy was one of the complementary therapies to improve CVDs.
This paper reviewed the EO on traditional treatment, preclinical mechanism and clinical application of CVDs. As important sources of traditional medicines, EO' remarkable efficacy had been confirmed in comprehensive literature reports, which showed that EO had great medicinal potential.
精油（EO）是从天然植物的不同部位提取的挥发性化合物，已被用于国家、传统和民间医学，以治疗世界各地的各种健康问题。有记录表明，在历史上，富含 EO 的草药在许多国家被广泛用于治疗 CVDs，如中国。
本综述通过多靶点协同作用，重点关注草药 EO 治疗 CVDs 的传统应用和现代药理学机制的临床前和临床试验。此外，比较了 EO 和抗 CVDs 药物，并从药物性质和芳香给药途径解释了 EO 的广泛应用。
从 Web of Science、ScienceDirect、PubMed 和中国国家知识基础设施（CNKI）等电子数据库中收集有关 EO 和 CVDs 的信息。对获得的数据进行了有序排列，以便更好地了解 EO 的潜力。
研究表明，自古以来，EO 在不同国家或地区的 CVDs 中具有重要的应用。针对 CVDs 的复杂病理机制，包括细胞内钙超载、氧化应激、炎症、血管内皮细胞损伤和功能障碍以及血脂异常，我们通过多靶点干预总结了 EO 在临床前和临床治疗 CVDs 的作用。此外，EO 具有药物和赋形剂的双重特性。芳香疗法是改善 CVDs 的补充疗法之一。
本文综述了 EO 对 CVDs 的传统治疗、临床前机制和临床应用。作为传统药物的重要来源，EO 在综合文献报告中已被证实具有显著疗效，表明 EO 具有巨大的药用潜力。
