Department of Chemistry, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.
Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Int J Mol Sci. 2024 Apr 30;25(9):4895. doi: 10.3390/ijms25094895.
Post-traumatic stress disorder (PTSD) is a debilitating psychological condition that may develop in certain individuals following exposure to life-threatening or traumatic events. Distressing symptoms, including flashbacks, are characterized by disrupted stress responses, fear, anxiety, avoidance tendencies, and disturbances in sleep patterns. The enduring effects of PTSD can profoundly impact personal and familial relationships, as well as social, medical, and financial stability. The prevalence of PTSD varies among different populations and is influenced by the nature of the traumatic event. Recently, zebrafish have emerged as a valuable model organism in studying various conditions and disorders. Zebrafish display robust behavioral patterns that can be effectively quantified using advanced video-tracking tools. Due to their relatively simple nervous system compared to humans, zebrafish are particularly well suited for behavioral investigations. These unique characteristics make zebrafish an appealing model for exploring the underlying molecular and genetic mechanisms that govern behavior, thus offering a powerful comparative platform for gaining deeper insights into PTSD. This review article aims to provide updates on the pathophysiology of PTSD and the genetic responses associated with psychological stress. Additionally, it highlights the significance of zebrafish behavior as a valuable tool for comprehending PTSD better. By leveraging zebrafish as a model organism, researchers can potentially uncover novel therapeutic interventions for the treatment of PTSD and contribute to a more comprehensive understanding of this complex condition.
创伤后应激障碍（PTSD）是一种使人虚弱的心理疾病，某些个体在经历危及生命或创伤性事件后可能会患上这种疾病。令人痛苦的症状，包括闪回，其特征是压力反应、恐惧、焦虑、回避倾向和睡眠模式紊乱。PTSD 的持久影响可能会深刻影响个人和家庭关系，以及社会、医疗和经济稳定。PTSD 的患病率在不同人群中有所不同，并且受到创伤事件性质的影响。最近，斑马鱼已成为研究各种疾病和障碍的有价值的模式生物。斑马鱼表现出强大的行为模式，可以使用先进的视频跟踪工具进行有效量化。由于其与人类相比相对简单的神经系统，斑马鱼特别适合进行行为研究。这些独特的特征使斑马鱼成为探索控制行为的潜在分子和遗传机制的有吸引力的模型，从而为深入了解 PTSD 提供了一个强大的比较平台。本文旨在提供 PTSD 的病理生理学和与心理压力相关的遗传反应的最新信息。此外，它还强调了斑马鱼行为作为更好地理解 PTSD 的有价值工具的重要性。通过将斑马鱼作为模式生物，研究人员可能会发现治疗 PTSD 的新的治疗干预措施，并为更全面地理解这种复杂疾病做出贡献。
