Qaiyumi S, Hassan Z U, Toone E
Arch Intern Med. 1985 May;145(5):822-4.
We evaluated 100 consecutive cases of lone aortic insufficiency (AI) for the prevalence of seronegative spondyloarthropathies. Four patients were found to have ankylosing spondylitis and three had Reiter's syndrome. Six of these seven patients had cardiac conduction abnormalities, four of which required permanent pacemaker insertion. All seven were found to have the HLA-B27 antigen, whereas of 89 patients tested with no evidence of spondylitis only five had the antigen. The seronegative spondyloarthropathies apparently are associated frequently with lone AI. The morbidity and mortality of these patients increases when they develop cardiovascular abnormalities including AI and heart block, which may dominate the clinical picture. The HLA-B27 antigen is not specifically associated with lone AI in the absence of spondylitis.
我们评估了100例连续性单纯主动脉瓣关闭不全（AI）患者血清阴性脊柱关节病的患病率。发现4例患者患有强直性脊柱炎，3例患有赖特综合征。这7例患者中有6例存在心脏传导异常，其中4例需要植入永久性起搏器。所有7例患者均检测出HLA - B27抗原，而在89例未发现脊柱炎证据的检测患者中，只有5例有该抗原。血清阴性脊柱关节病显然常与单纯AI相关。当这些患者出现包括AI和心脏传导阻滞在内的心血管异常时，其发病率和死亡率会增加，而这些异常可能主导临床表现。在无脊柱炎的情况下，HLA - B27抗原与单纯AI无特异性关联。
