Zahra Fatima Tuz, Zhang Ying, Ajayi Adeolu Oluwaseun, Quick Quincy, Mu Richard
TIGER Institute, Tennessee State University, Nashville, TN 37209, USA.
Center for Manufacturing Research, Tennessee Technological University, Cookeville, TN 38505, USA.
Polymers (Basel). 2024 Apr 26;16(9):1217. doi: 10.3390/polym16091217.
Polyvinylpyrrolidone (PVP) is a synthetic polymer that holds significance in various fields such as biomedical, medical, and electronics, due to its biocompatibility and exceptional dielectric properties. Electrospinning is the most commonly used tool to fabricate fibers because of its convenience and the wide choice of parameter optimization. Various parameters, including solution molarity, flow rate, voltage, needle gauge, and needle-to-collector distance, can be optimized to obtain the desired morphology of the fibers. Although PVP is commercially available in various molecular weights, PVP with a molecular weight of 130,000 g/mol is generally considered to be the easiest PVP to fabricate fibers with minimal challenges. However, the fiber diameter in this case is usually in the micron regime, which limits the utilization of PVP fibers in fields that require fiber diameters in the nano regime. Generally, PVP with a lower molecular weight, such as 10,000 g/mol and 55,000 g/mol, is known to present challenges in fiber preparation. In the current study, parameter optimization for PVP possessing molecular weights of 10,000 g/mol and 55,000 g/mol was carried out to obtain nanofibers. The electrospinning technique was utilized for fiber fabrication by optimizing the above-mentioned parameters. SEM analysis was performed to analyze the fiber morphology, and quantitative analysis was performed to correlate the effect of parameters on the fiber morphology. This research study will lead to various applications, such as drug encapsulation for sustained drug release and nanoparticles/nanotubes encapsulation for microwave absorption applications.
聚乙烯吡咯烷酮（PVP）是一种合成聚合物，因其生物相容性和优异的介电性能，在生物医学、医疗和电子等各个领域都具有重要意义。由于其便利性和参数优化的广泛选择，静电纺丝是制造纤维最常用的方法。可以优化各种参数，包括溶液摩尔浓度、流速、电压、针规和针头到收集器的距离，以获得所需的纤维形态。虽然PVP有各种分子量的商业产品，但分子量为130,000 g/mol的PVP通常被认为是最容易制造纤维且挑战最小的PVP。然而，在这种情况下，纤维直径通常处于微米级，这限制了PVP纤维在需要纳米级纤维直径的领域中的应用。一般来说，较低分子量的PVP，如10,000 g/mol和55,000 g/mol，在纤维制备中存在挑战。在本研究中，对分子量为10,000 g/mol和55,000 g/mol的PVP进行了参数优化，以获得纳米纤维。通过优化上述参数，利用静电纺丝技术制造纤维。进行扫描电子显微镜（SEM）分析以分析纤维形态，并进行定量分析以关联参数对纤维形态的影响。这项研究将带来各种应用，如用于药物缓释的药物包封以及用于微波吸收应用的纳米颗粒/纳米管包封。
