Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
Department of Biomedical Engineering, Tiangong, Tianjin 300387, China.
Mar Drugs. 2024 Sep 27;22(10):443. doi: 10.3390/md22100443.
The electrospinning of pure chitosan nanofibers is highly sensitive to environmental humidity, which limits their production consistency and applicability. This study investigates the addition of sodium chloride (NaCl) to chitosan solutions to enhance spinnability and mitigate the effigurefects of low humidity. NaCl was incorporated into the electrospun chitosan solution, leading to increased conductivity and decreased viscosity. These modifications improved the electrospinning process. Comparative analyses between chitosan membranes (CM) and sodium-chloride-added chitosan membranes (SCM) revealed no significant differences in chemical structure, mechanical strength, or in vitro cell proliferation. This indicates that the addition of 1% (/) NaCl does not adversely affect the fundamental properties of the chitosan membranes. The findings demonstrate that NaCl addition is a viable strategy for producing electrospun chitosan nanofibers in low-humidity environments, maintaining their physicochemical properties while enhancing spinnability.
静电纺丝纯壳聚糖纳米纤维对环境湿度非常敏感，这限制了它们的生产一致性和适用性。本研究探讨了向壳聚糖溶液中添加氯化钠（NaCl）以提高可纺性并减轻低湿度的影响。NaCl 被掺入到静电纺丝壳聚糖溶液中，导致导电性增加和粘度降低。这些改进改善了静电纺丝过程。壳聚糖膜（CM）和添加氯化钠的壳聚糖膜（SCM）之间的比较分析表明，它们在化学结构、机械强度或体外细胞增殖方面没有显著差异。这表明添加 1%（/）NaCl 不会对壳聚糖膜的基本性质产生不利影响。研究结果表明，添加 NaCl 是在低湿度环境中生产静电纺丝壳聚糖纳米纤维的一种可行策略，在保持其物理化学性质的同时提高可纺性。
