Pathological and adaptive vascular changes in the microcirculatory bed according to morphological and biomicroscopic findings.

Using non-injection methods (membrane silvering, their staining with Sudan black B or Schiff's reagent) and using conjunctival microscopy, the state of microcirculation in various diseases was investigated on autopsy material (162 observations) and in vivo (78 patients). On the basis of the results the authors deduce general principles of the description and functional evaluation of pathological changes in the microcirculatory system, and divide them into vascular, intravascular and extravascular (stromal) ones. They stress that besides pathological changes proper it is necessary to differentiate also adaptive changes in the microvascular structure, changes in rheological properties of blood and in the interstitium. It is recommended to apply the same principles in description and functional evaluation of the findings of biomicroscopic examination of microcirculation in clinical practice.