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实验性构建机械性皮肤损伤和化学性烧伤导致的瘢痕模型：SD 大鼠模型。

Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats.

机构信息

Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region, Russia.

Pushchino Branch of Russian Biotechnological University (ROSBIOTECH), Pushchino, Moscow Region, Russia.

出版信息

Bull Exp Biol Med. 2024 Mar;176(5):640-644. doi: 10.1007/s10517-024-06084-1. Epub 2024 May 11.

DOI:10.1007/s10517-024-06084-1
PMID:38733481
Abstract

Creating of a scar model in laboratory animals is the most acceptable option for the preclinical search of scar treatment. However, due to high skin regeneration rate in laboratory rodents, creating an optimal animal model of scar formation is a challenge. Here we describe five methods for modeling a scar tissue in rats that we have tested. These methods allowed achieving different histopathological features and different stages of skin scar formation.

摘要

在实验室动物中创建疤痕模型是临床前疤痕治疗研究最可接受的选择。然而，由于实验室啮齿动物的皮肤再生速度较快，因此创建理想的疤痕形成动物模型是一个挑战。在这里，我们描述了五种在大鼠中建模疤痕组织的方法，我们已经对这些方法进行了测试。这些方法可以实现不同的组织病理学特征和不同阶段的皮肤疤痕形成。

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Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats.实验性构建机械性皮肤损伤和化学性烧伤导致的瘢痕模型：SD 大鼠模型。
Bull Exp Biol Med. 2024 Mar;176(5):640-644. doi: 10.1007/s10517-024-06084-1. Epub 2024 May 11.
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本文引用的文献

1
In Vivo Models for Hypertrophic Scars-A Systematic Review.体内增生性瘢痕模型的系统评价。
Medicina (Kaunas). 2022 May 30;58(6):736. doi: 10.3390/medicina58060736.
2
Bioengineered Wound Healing Skin Models: The Role of Immune Response and Endogenous ECM to Fully Replicate the Dynamic of Scar Tissue Formation In Vitro.生物工程化伤口愈合皮肤模型：免疫反应和内源性细胞外基质在体外完全复制瘢痕组织形成动态过程中的作用。
Bioengineering (Basel). 2022 May 27;9(6):233. doi: 10.3390/bioengineering9060233.
3
A novel rat tail disc degeneration model induced by static bending and compression.
一种新型的由静态弯曲和压缩导致的大鼠尾椎间盘退变模型。
Animal Model Exp Med. 2021 Aug 26;4(3):261-267. doi: 10.1002/ame2.12178. eCollection 2021 Sep.
4
Cutaneous Wound Healing after Topical Application of Gel Formulation in Rats.大鼠局部应用凝胶制剂后的皮肤伤口愈合
Turk J Pharm Sci. 2017 Apr;14(1):65-74. doi: 10.4274/tjps.41713. Epub 2017 Apr 15.
5
The Evolution of Animal Models in Wound Healing Research: 1993-2017.1993 - 2017年伤口愈合研究中动物模型的演变
Adv Wound Care (New Rochelle). 2019 Dec 1;8(12):692-702. doi: 10.1089/wound.2019.1098. Epub 2019 Nov 6.
6
A Novel Model for Cutaneous Wound Healing and Scarring in the Rat.一种新型大鼠皮肤创伤愈合和瘢痕形成模型。
Plast Reconstr Surg. 2019 Feb;143(2):468-477. doi: 10.1097/PRS.0000000000005274.
7
Fractional CO laser treatment for vaginal laxity: A preclinical study.剥脱性二氧化碳激光治疗阴道松弛：一项临床前研究。
Lasers Surg Med. 2018 Sep;50(9):940-947. doi: 10.1002/lsm.22940. Epub 2018 May 7.