Piruzian L A, Mukumov M R, Sorokin L V, Afanas'eva N M
Farmakol Toksikol. 1985 Mar-Apr;48(2):69-72.
The action of bacterial lipopolysaccharides (pyrogenal and prodigiosan) on nervous regulation of the frog heart was studied. Both the substances provoked a considerable increase in the arrest of spontaneous contractility of the atria during stimulation of the extracardial nerves. This effect did not occur after atropine administration, but became manifest during the benzohexonium-induced blockade of conduction in the intracardiac ganglia. The bacterial lipopolysaccharides did not alter acetylcholinesterase activity or myocardial sensitivity to acetylcholine. It is assumed that variation of the nervous regulation of the heart under the effect of prodigiosan and pyrogenal is determined by the effect of these substances on the transmitter release from the presynaptic endings of the extracardial ganglia.
研究了细菌脂多糖（热原质和灵菌红素）对蛙心神经调节的作用。这两种物质在刺激心外神经时，均引起心房自发性收缩停止的显著增加。给予阿托品后这种效应未出现，但在苯己铵诱导的心内神经节传导阻滞期间则表现出来。细菌脂多糖未改变乙酰胆碱酯酶活性或心肌对乙酰胆碱的敏感性。据推测，灵菌红素和热原质作用下心脏神经调节的变化是由这些物质对心外神经节突触前末梢递质释放的影响所决定的。
