Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan; Oral Medicine Research Center, Fukuoka Dental College, Fukuoka, Japan.
Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan.
J Oral Biosci. 2024 Jun;66(2):314-319. doi: 10.1016/j.job.2024.05.002. Epub 2024 May 9.
Odontogenic tumors arise in the jawbone and originate from cells associated with tooth development. Therefore, understanding odontogenic tumors requires knowledge of all aspects of dental research, including tooth development and eruption. Ameloblastoma is the most common odontogenic tumor.
Although a benign tumor, ameloblastoma progresses with marked jawbone resorption. Because of its locally aggressive features, it can be treated surgically by resecting the surrounding bone. From a molecular pathology perspective, several genetic mutations and dysregulated signaling pathways involved in ameloblastoma tumorigenesis have been identified. Histopathologically, ameloblastomas consist of peripheral ameloblast-like cells and an inner stellate reticulum. The stromal region consists of fibrovascular connective tissue, showing a characteristic sparse myxoid histology. In general, the tumor microenvironment, including the surrounding non-tumor cells, contributes to tumorigenesis and progression. In this review, we focus on the tumor microenvironment of ameloblastomas. In addition, we present some of our recent studies on osteoclastogenesis, tubulin acetylation-induced cell migration, and hypoxia-induced epithelial-mesenchymal transition in ameloblastomas.
Further research on ameloblastomas can lead to the development of new treatments and improve patients' quality of life.
牙源性肿瘤起源于颌骨，来源于与牙齿发育相关的细胞。因此，了解牙源性肿瘤需要了解牙齿研究的各个方面，包括牙齿发育和萌出。造釉细胞瘤是最常见的牙源性肿瘤。
尽管是良性肿瘤，但造釉细胞瘤会导致明显的颌骨吸收。由于其局部侵袭性特征，可通过切除周围骨骼进行手术治疗。从分子病理学的角度来看，已经确定了几种与造釉细胞瘤肿瘤发生相关的遗传突变和失调的信号通路。组织病理学上，造釉细胞瘤由外周造釉细胞样细胞和内部星状网状细胞组成。基质区域由纤维血管结缔组织组成，表现出特征性稀疏粘液样组织学。一般来说，肿瘤微环境，包括周围的非肿瘤细胞，有助于肿瘤的发生和进展。在这篇综述中，我们重点介绍造釉细胞瘤的肿瘤微环境。此外，我们还介绍了我们最近在造釉细胞瘤中的破骨细胞发生、微管乙酰化诱导的细胞迁移和缺氧诱导的上皮-间充质转化方面的一些研究。
对造釉细胞瘤的进一步研究可以开发出新的治疗方法，提高患者的生活质量。
