B CUBE - Center for Molecular Bioengineering, TUD Dresden University of Technology, 01307 Dresden, Germany.
B CUBE - Center for Molecular Bioengineering, TUD Dresden University of Technology, 01307 Dresden, Germany; Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany; Cluster of Excellence Physics of Life, TUD Dresden University of Technology, 01062 Dresden, Germany.
Curr Opin Cell Biol. 2024 Jun;88:102367. doi: 10.1016/j.ceb.2024.102367. Epub 2024 May 11.
Microtubule motors play key roles in cellular functions, such as transport, mitosis and cell motility. Fueled by ATP hydrolysis, they convert chemical energy into mechanical work, which enables their movement on microtubules. While their motion along the long axis of microtubules has been studied extensively, some motors display an off-axis component, which results in helical motion around microtubules and the generation of torque in addition to linear forces. Understanding these nuanced movements expands our comprehension of motor protein dynamics and their impact on cellular processes.
微管马达在细胞功能中发挥着关键作用，如运输、有丝分裂和细胞运动。它们通过 ATP 水解供能，将化学能转化为机械能，从而能够在微管上运动。虽然它们沿着微管的长轴运动已经被广泛研究，但一些马达显示出了离轴成分，这导致了它们在微管周围产生螺旋运动，并产生扭矩以及线性力。理解这些细微的运动扩展了我们对马达蛋白动力学及其对细胞过程影响的理解。
