Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
J Affect Disord. 2024 Aug 1;358:391-398. doi: 10.1016/j.jad.2024.05.055. Epub 2024 May 10.
Personality traits, especially neuroticism, can influence susceptibility to dementia. Social contact mitigates stress and risk of dementia, the extent to which social contact can mitigate excess risk associated with neuroticism remains unclear. We aim to investigate whether active social contact is associated with lower neuroticism-associated excess risk of dementia.
This prospective cohort study examined 393,939 UK Biobank participants (mean [SD] age: 56.4 [8.1] years; 53.7 % female) assessed from 2006 to 2010 and followed up until December 2022. Neuroticism was measured using the Revised Eysenck Personality Questionnaire. Social contact levels were assessed based on household size, contact with family or friends, and group participation. Dementia was determined using linked electronic health records.
High neuroticism was associated with increased all-cause dementia risk and cause-specific dementia. Among high neuroticism participants, excess risk of all-cause dementia showed a stepwise decrease with increasing social contact (low: hazard ratios (HR) = 1.27, 95 % confidence interval (CI) = 1.15-1.40; intermediate: HR = 1.20, 95 % CI = 1.12-1.28; high: HR = 1.07, 95 % CI = 1.00-1.15). High social contact similarly decreased excess risk of cause-specific dementia, comparable to those with low neuroticism.
Neuroticism and social contact information relied on self-report questionnaires at baseline, with a potential temporal relationship between these factors.
Active social contact is associated with a stepwise reduction in excess dementia risk and potentially eliminate excess risk of dementia with high neuroticism individuals, supporting social contact as a preventive strategy to attenuate excess risks of dementia from neuroticism personality trait.
人格特质，尤其是神经质，会影响痴呆症的易感性。社会接触可以减轻压力和痴呆症的风险，但社会接触可以减轻与神经质相关的过度风险的程度尚不清楚。我们旨在研究积极的社会接触是否与较低的神经质相关的痴呆症过度风险有关。
这项前瞻性队列研究调查了 393939 名英国生物库参与者（平均[标准差]年龄：56.4[8.1]岁；53.7%为女性），他们在 2006 年至 2010 年进行了评估，并随访至 2022 年 12 月。神经质使用修订后的艾森克人格问卷进行测量。社会接触水平根据家庭规模、与家人或朋友的接触以及群体参与情况进行评估。痴呆症通过链接的电子健康记录确定。
高神经质与全因痴呆症风险和特定病因痴呆症风险增加有关。在高神经质参与者中，随着社会接触的增加，全因痴呆症的过度风险呈逐步下降趋势（低：危险比[HR] = 1.27，95%置信区间[CI] = 1.15-1.40；中：HR = 1.20，95%CI = 1.12-1.28；高：HR = 1.07，95%CI = 1.00-1.15）。高社会接触同样降低了特定病因痴呆症的过度风险，与低神经质者相当。
神经质和社会接触信息依赖于基线时的自我报告问卷，这些因素之间存在潜在的时间关系。
积极的社会接触与痴呆症过度风险的逐步降低相关，并可能消除高神经质个体痴呆症的过度风险，支持社会接触作为减轻神经质人格特质导致的痴呆症过度风险的预防策略。
