Liu Yufei, Chang Jie, Zhao Yiwei, Gao Peiyang, Tang Yi
Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
J Affect Disord. 2025 Apr 15;375:129-136. doi: 10.1016/j.jad.2025.01.112. Epub 2025 Jan 23.
Frailty and social contact are significant factors influencing dementia risk. While previous studies have separately examined these factors, their combined impact on dementia remains underexplored.
This study included 338,567 UK biobank participants from 2006 to 2010, with follow-up until December 2022. Additionally, 30,408 participants with brain magnetic resonance imaging data were analyzed for hippocampal volume. Cox proportional hazards regression and linear regression models were used to assess associations.
The study followed 338,567 participants (mean [SD] age, 60.4 [5.2] years; 54.1 % men) for a median of 13.7 years, documenting 7362 cases of all-cause dementia. Both frailty and lower social contact independently increased the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD). Compared to individuals with non-frailty and high social contact, those with lower social contact and higher frailty had a significantly increased risk of all-cause dementia, with the highest risk observed in individuals with frailty and low social contact (HR = 2.65, 95 % CI: 2.27-3.11). Similar patterns were found for AD and VaD. Furthermore, hippocampal volume was significantly reduced in individuals with frailty and low social contact (β = -0.24, 95 % CI: -0.43 to -0.06) compared to those with non-frailty and high social contact.
The study predominantly included European descent individuals, with most frailty and social contact data based on baseline self-reports.
The combination of frailty and low social contact is associated with the highest risk of dementia. These findings suggest that both physiological and social factors should be simultaneously considered in dementia prevention strategies.
衰弱和社交接触是影响痴呆风险的重要因素。虽然先前的研究分别考察了这些因素，但它们对痴呆的综合影响仍未得到充分探索。
本研究纳入了2006年至2010年英国生物银行的338567名参与者，随访至2022年12月。此外，对30408名有脑磁共振成像数据的参与者进行了海马体积分析。采用Cox比例风险回归模型和线性回归模型评估相关性。
该研究对338567名参与者（平均[标准差]年龄，60.4[5.2]岁；54.1%为男性）进行了中位数为13.7年的随访，记录了7362例全因性痴呆病例。衰弱和社交接触较少均独立增加了全因性痴呆、阿尔茨海默病（AD）和血管性痴呆（VaD）的风险。与非衰弱且社交接触频繁的个体相比，社交接触较少且衰弱程度较高的个体患全因性痴呆的风险显著增加，在衰弱且社交接触较少的个体中观察到的风险最高（风险比=2.65，95%置信区间：2.27-3.11）。AD和VaD也发现了类似的模式。此外，与非衰弱且社交接触频繁的个体相比，衰弱且社交接触较少的个体海马体积显著减小（β=-0.24，95%置信区间：-0.43至-0.06）。
该研究主要纳入了欧洲血统个体，大多数衰弱和社交接触数据基于基线自我报告。
衰弱和社交接触较少的组合与痴呆风险最高相关。这些发现表明，在痴呆预防策略中应同时考虑生理和社会因素。
