Post Graduate Resident, Department of Internal Medicine, Acharya Shri Chander College of Medical Sciences & Hospital, Jammu, Jammu and Kashmir, India, Corresponding Author.
Professor, Department of Internal Medicine, Acharya Shri Chander College of Medical Sciences & Hospital, Jammu, Jammu and Kashmir, India.
J Assoc Physicians India. 2024 Jan;72(1):28-31. doi: 10.59556/japi.71.0434.
A group of characteristics known as metabolic syndrome raises the chance of developing diabetes and cardiovascular disease. Insulin resistance (IR) and obesity are regarded as critical metabolic syndrome pathophysiology.
The diagnostic accuracy of IR indicators, triglyceride (TG) glucose index-neck circumference (TyG-NC), and TG glucose index-neck-to-height ratio (TyG-NHtR) to be evaluated for the detection of cardiovascular diseases and metabolic syndrome in nondiabetic individuals.
A cross-sectional study was conducted and passed by the Ethics Committee of the institute. The age should be 18 years or older, and subjects should not have diabetes. Each patient's clinical information was gathered, and lab tests were run. The study was done for a period of 1 year.
The study has 100 participants. Around 74% of the group was women. Only 26.5% of the group had an obesity diagnosis. Poor fasting plasma glucose levels were found in 19.4% of the research team. Receiver operating characteristic (ROC)-area under the curve (AUC) testing revealed that all examined IR indices can differentiate individuals with metabolic syndrome from those who are healthy. Our analysis laid out the soaring high area under the ROC curve for TyG index and the low stunted area under the ROC curve for TyG-NC. For obesity, all indices showed appreciable diagnostic efficacy, indicating the maximum achieved area under the ROC curve for TyG index and the minimum recorded metabolic score for IR. The AUC in the case of the metabolic score for IR (METS-IR) male sample population was found to be not statistically compelling.
The exploration of indirect indices, the proposed ones, namely TyG-NC and TyG-NHtR, emphasized an intricate link between cardiovascular diseases and metabolic syndrome.
一组被称为代谢综合征的特征会增加患糖尿病和心血管疾病的风险。胰岛素抵抗（IR）和肥胖被认为是代谢综合征病理生理学的关键。
评估 IR 指标、三酰甘油（TG）葡萄糖指数-颈围（TyG-NC）和 TG 葡萄糖指数-颈高比（TyG-NHtR）的诊断准确性，以检测非糖尿病个体的心血管疾病和代谢综合征。
进行了一项横断面研究，并通过了研究所的伦理委员会的审查。年龄应在 18 岁或以上，且患者不应患有糖尿病。收集每位患者的临床信息并进行实验室检查。研究时间为 1 年。
该研究共有 100 名参与者。研究组中约 74%为女性。仅有 26.5%的组被诊断为肥胖。研究组中有 19.4%的人空腹血糖水平较差。受试者工作特征（ROC）-曲线下面积（AUC）测试表明，所有检查的 IR 指数都可以区分代谢综合征患者和健康人群。我们的分析表明，TyG 指数的 ROC 曲线下面积较高，而 TyG-NC 的 ROC 曲线下面积较低。对于肥胖，所有指数均显示出相当的诊断效果，表明 TyG 指数的最大达到 ROC 曲线下面积和 IR 的最低代谢评分。IR 代谢评分（METS-IR）男性样本人群的 AUC 没有统计学意义。
对间接指标的探索，即提出的 TyG-NC 和 TyG-NHtR，强调了心血管疾病和代谢综合征之间的复杂联系。
