First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Front Endocrinol (Lausanne). 2024 Apr 26;15:1365327. doi: 10.3389/fendo.2024.1365327. eCollection 2024.
Endometriosis is a chronic inflammatory gynecological disease, which profoundly jeopardizes women's quality of life and places a significant medical burden on society. The pathogenesis of endometriosis remains unclear, posing major clinical challenges in diagnosis and treatment. There is an urgent demand for the development of innovative non-invasive diagnostic techniques and the identification of therapeutic targets. Extracellular vesicles, recognized for transporting a diverse array of signaling molecules, have garnered extensive attention as a novel mode of intercellular communication. A burgeoning body of research indicates that extracellular vesicles play a pivotal role in the pathogenesis of endometriosis, which may provide possibility and prospect for both diagnosis and treatment. In light of this context, this article focuses on the involvement of extracellular vesicles in the pathogenesis of endometriosis, which deliver information among endometrial stromal cells, macrophages, mesenchymal stem cells, and other cells, and explores their potential applications in the diagnosis and treatment, conducing to the emergence of new strategies for clinical diagnosis and treatment.
子宫内膜异位症是一种慢性炎症性妇科疾病，严重影响妇女的生活质量，并给社会带来沉重的医疗负担。子宫内膜异位症的发病机制尚不清楚，这给诊断和治疗带来了重大的临床挑战。因此迫切需要开发创新的非侵入性诊断技术和治疗靶点。细胞外囊泡作为一种新型的细胞间通讯方式，因其能够运输多种信号分子而受到广泛关注。越来越多的研究表明，细胞外囊泡在子宫内膜异位症的发病机制中起关键作用，这可能为诊断和治疗提供了可能性和前景。有鉴于此，本文重点关注细胞外囊泡在子宫内膜异位症发病机制中的作用，探讨其在子宫内膜间质细胞、巨噬细胞、间充质干细胞等细胞间传递信息的作用，并探讨其在诊断和治疗中的潜在应用，为临床诊断和治疗新策略的出现奠定了基础。
