Frick M H, Valle M, Harjola P T
Acta Med Scand Suppl. 1985;694:207-10. doi: 10.1111/j.0954-6820.1985.tb08816.x.
One hundred patients with angina pectoris were randomly allocated for medical therapy and bypass surgery in groups of 50 patients each. The effect of the respective therapies was assessed by annual exercise testing for up to five years. The surgical group was also studied by postoperative coronary angiograms at three weeks, one year and five years after the operation. The medical group was subjected to repeated coronary angiography five years after randomization. All of the variables depicting exercise tolerance were significantly improved in the surgical group but remained largely at the initial level in the medical group. A subgroup analysis of the surgical series revealed that the sustained improvement was largely confined to the completely revascularized subset of patients. The slowly increasing use of beta blocking compounds in the surgical group also contributed to the favourable results for bypass surgery.
100例心绞痛患者被随机分为两组，每组50例，分别接受药物治疗和搭桥手术。通过每年进行运动试验，持续五年评估各自治疗方法的效果。手术组还在术后三周、一年和五年进行冠状动脉造影研究。药物组在随机分组五年后接受重复冠状动脉造影。所有描述运动耐量的变量在手术组均有显著改善，但在药物组基本维持在初始水平。手术系列的亚组分析显示，持续改善主要局限于完全血运重建的患者亚组。手术组中β受体阻滞剂的使用逐渐增加，这也促成了搭桥手术的良好效果。
