正常人T淋巴细胞和B淋巴细胞在低密度脂蛋白结合、内化及分解代谢方面的差异。
Differences in the binding, internalization and catabolism of low-density lipoprotein between normal human T and B lymphocytes.
作者信息
Sanghvi A, Warty V
出版信息
Biochem J. 1985 Apr 15;227(2):397-404. doi: 10.1042/bj2270397.
Abstract
Studies in human peripheral blood B and T lymphocytes show that high-affinity binding of low-density lipoprotein (LDL) to the cell surface receptor and the kinetics of binding are comparable between B and T lymphocytes, but the internalization of receptor-bound LDL in B cells appears deficient. Yet, the fraction of internalized LDL degraded by both B and T lymphocytes is of similar magnitude. Moreover, the lysosomal acid cholesterol ester hydrolase and acyl-CoA:cholesterol acyltransferase activities in B cell were about one-third of those in T lymphocytes. These data suggest deficient LDL catabolism in B lymphocytes relative to that in T lymphocytes.
摘要
对人类外周血B淋巴细胞和T淋巴细胞的研究表明，低密度脂蛋白（LDL）与细胞表面受体的高亲和力结合以及结合动力学在B淋巴细胞和T淋巴细胞之间具有可比性，但B细胞中受体结合的LDL的内化似乎存在缺陷。然而，B淋巴细胞和T淋巴细胞降解的内化LDL部分数量相似。此外，B细胞中的溶酶体酸性胆固醇酯水解酶和酰基辅酶A：胆固醇酰基转移酶活性约为T淋巴细胞中的三分之一。这些数据表明，相对于T淋巴细胞，B淋巴细胞中的LDL分解代谢存在缺陷。
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