The Research Unit for Dietary Studies, The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark.
Steno Diabetes Center Sjælland, Herlev, Denmark.
PLoS One. 2024 May 13;19(5):e0302010. doi: 10.1371/journal.pone.0302010. eCollection 2024.
Pregnancy increases the risk of periodontitis due to the increase in progesterone and estrogen. Moreover, periodontitis during pregnancy is associated with development of pregnancy and birth related complications. The aim of this study is to determine, whether periodontal treatment during pregnancy can reduce systemic inflammation and lower the risk of adverse pregnancy and birth related outcomes.
The PROBE study is a non-randomized controlled intervention study conducted among 600 pregnant women with periodontitis. The women will be recruited among all pregnant women at two Danish hospitals in Region Zealand during their nuchal translucency scan and will subsequently be screened for periodontitis. The intervention group includes 300 pregnant women, who will be offered state-of-the-art periodontal treatment during pregnancy. The control group includes additional 300 pregnant women, who will be offered periodontal treatment after giving birth. Outcome measures include periodontal measures, inflammatory, hormonal and glycaemic markers as well as the prevalence of preterm birth risk, low birth weight and risk markers of gestational diabetes mellitus (GDM) and preeclampsia that will be collected from all screened women and further during pregnancy week 20 and pregnancy week 35 for women enrolled in the intervention.
The study's findings will be published in peer reviewed journals and disseminated at national and international conferences and through social media. The PROBE study is designed to provide important new knowledge as to whether periodontal treatment during pregnancy can reduce the prevalence of complications related to pregnancy and birth.
The study was registered on clinicaltrials.gov (NCT06110143).
怀孕会导致孕激素和雌激素增加，从而增加牙周炎的风险。此外，怀孕期间的牙周炎与妊娠和分娩相关并发症的发展有关。本研究旨在确定怀孕期间的牙周治疗是否可以减轻全身炎症并降低不良妊娠和分娩相关结局的风险。
PROBE 研究是一项非随机对照干预研究，纳入了 600 名患有牙周炎的孕妇。这些妇女将在丹麦 Region Zealand 的两家医院进行颈部透明带扫描时被招募，并随后接受牙周炎筛查。干预组包括 300 名孕妇，她们将在怀孕期间接受最先进的牙周治疗。对照组包括另外 300 名孕妇，她们将在分娩后接受牙周治疗。主要观察指标包括牙周措施、炎症、激素和血糖标志物，以及早产风险、低出生体重和妊娠期糖尿病 (GDM) 和子痫前期的风险标志物的发生率，这些都将从所有筛查妇女中收集，并在干预组中招募的妇女妊娠第 20 周和第 35 周进一步收集。
该研究的结果将发表在同行评议的期刊上，并在国家和国际会议上以及通过社交媒体进行传播。PROBE 研究旨在提供有关怀孕期间牙周治疗是否可以降低与妊娠和分娩相关并发症发生率的重要新信息。
该研究已在 clinicaltrials.gov（NCT06110143）上注册。
