Włodarski K, Rychlik G, Mazur S
Immunology. 1985 Jun;55(2):311-5.
Activation of lymph nodes by the T-cell mitogens PHA and Con A is correlated with a depletion of lymphatic mast cells. This result, and our earlier reports on the depletion of mast cells in lymph nodes stimulated by allogeneic and tumour cells, as well as on the elevation of mast cell number in thymus-less 'nude' mice, lead us to the conclusion that antigen- or mitogen-stimulated T lymphocytes produce lymphokine(s) which degranulates mast cells and/or is responsible for their negative chemotaxis.
T细胞丝裂原PHA和Con A激活淋巴结与淋巴组织肥大细胞的减少相关。这一结果,以及我们之前关于同种异体和肿瘤细胞刺激淋巴结导致肥大细胞减少,以及无胸腺“裸”鼠肥大细胞数量增加的报道,使我们得出结论:抗原或丝裂原刺激的T淋巴细胞产生淋巴因子,使肥大细胞脱颗粒和/或导致其负趋化性。