Ricci M, Del Prete G F, Maggi E, Lanzavecchia A, Sala P G, Romagnani S
Int Arch Allergy Appl Immunol. 1985;77(1-2):32-7. doi: 10.1159/000233749.
In the last 5 years some models of human IgE production in vitro have been investigated in our laboratory. Spontaneous IgE synthesis was found in cultures of B cells from most patients with atopic dermatitis or atopic patients with multiple sensitivities and from some patients with pollenosis, but only during the pollination period. A small and variable increase of the spontaneous IgE synthesis was induced by soluble factor(s) produced by T cells from patients with severe atopy. Selected helper T cell clones were also able to induce IgE synthesis in vitro by both atopic and normal B cells.
在过去5年中，我们实验室对一些体外人IgE产生模型进行了研究。在大多数特应性皮炎患者或具有多种敏感性的特应性患者以及一些花粉症患者的B细胞培养物中发现了自发IgE合成，但仅在授粉期出现。重度特应性患者的T细胞产生的可溶性因子可诱导自发IgE合成出现少量且可变的增加。选定的辅助性T细胞克隆也能够在体外诱导特应性和正常B细胞产生IgE合成。
