Chiesa-Estomba Carlos M, Mayo-Yanez Miguel, Vaira Luigi A, Maniaci Antonino, Feng Allen L, Landa-Garmendia Maria, Cardin-Pereda Adrian, Lechien Jerome R
Otorhinolaryngology-Head & Neck Surgery Department, Donostia University Hospital, BioGuipuzkoa Research Institute, Faculty Of Medicine, Deusto University, 20014 Donostia, Spain.
Head & Neck Section-Research Committee of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), 13005 Marseille, France.
Biomedicines. 2024 Sep 4;12(9):2024. doi: 10.3390/biomedicines12092024.
(1) Background: Oral cavity cancer represents the most common site of origin of head and neck mucosal malignancies. A few limited studies have suggested that chronic irritation, particularly in non-healing ulcers, and fibrotic tissue from poor dentition or ill-fitting dentures had a role in developing mouth cancer. This scoping review aims to evaluate the existing evidence concerning Oral Cavicty Cancer (OCC) in non-smokers/non-drinkers and the relationship with dental trauma. (2) Methods: A scoping review of the PubMed, Embase, and Web of Science databases was completed in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist. (3) Results: Of the 33 articles that met inclusion, in 6 of them authors discussed the role of topography in dental trauma, in 11 articles authors discussed the carcinogenesis mechanism involved in chronic mucosal trauma, in 17 articles data on ill-fitting dentures was included, 4 studies dealt with the effect of broken/sharp teeth on mucosal damage, and in 7 studies the role of oral hygiene was covered. Less frequently discussed topics included gender, risk of neck nodes, and the role of potentially malignant oral disorders. (4) Conclusions: The available literature suggests a potential connection between chronic dental trauma and the development of OCC. Studies have highlighted factors such as denture use and ill-fitting dental appliances as contributors to an increased risk of oral cancer. Interestingly, we still miss data to support the hypothesis that women, particularly those without toxic habits like smoking or alcohol consumption, appear to be disproportionately affected by oral cancer related to chronic dental trauma.
(1) 背景：口腔癌是头颈部黏膜恶性肿瘤最常见的起源部位。一些有限的研究表明，慢性刺激，特别是在不愈合溃疡中，以及牙列不良或假牙不合适导致的纤维化组织在口腔癌的发生中起作用。本综述旨在评估非吸烟者/非饮酒者口腔癌（OCC）的现有证据以及与牙外伤的关系。(2) 方法：按照系统评价和Meta分析扩展的范围综述清单的首选报告项目，完成了对PubMed、Embase和Web of Science数据库的范围综述。(3) 结果：在符合纳入标准的33篇文章中，6篇文章的作者讨论了牙外伤中局部解剖学的作用，11篇文章的作者讨论了慢性黏膜创伤的致癌机制，17篇文章纳入了关于不合适假牙的数据，4项研究涉及破损/尖锐牙齿对黏膜损伤的影响，7项研究涵盖了口腔卫生的作用。较少讨论的主题包括性别、颈部淋巴结风险以及潜在恶性口腔疾病的作用。(4) 结论：现有文献表明慢性牙外伤与口腔癌的发生之间可能存在联系。研究强调了使用假牙和不合适的牙科器具等因素是口腔癌风险增加的原因。有趣的是，我们仍然缺乏数据来支持这样的假设，即女性，特别是那些没有吸烟或饮酒等不良习惯的女性，似乎受到与慢性牙外伤相关的口腔癌的影响不成比例。
