• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新获得的亲嗜性Emv-18前病毒在Fv-2同源近交系小鼠中的组织特异性表达。

Tissue-specific expression of the newly acquired ecotropic Emv-18 provirus in Fv-2 congenic mice.

作者信息

Robson I B, Mowat M, Bernstein A

出版信息

J Virol. 1985 Jul;55(1):54-9. doi: 10.1128/JVI.55.1.54-59.1985.

DOI:10.1128/JVI.55.1.54-59.1985
PMID:3874291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254897/
Abstract

Expression of endogenous retroviral sequences in Fv-2 congenic mouse strains was examined by Northern blot analysis. Endogenous ecotropic virus transcripts were observed in total spleen RNA of B6.S (Fv-2ss) mice. Endogenous ecotropic transcripts were not detected in spleen RNA of C57BL/6, the Fv-2rr congenic partner of B6.S, nor in spleens of the C57BL/10 (Fv-2rr) and B10.C (Fv-2ss) congenic strains. Mendelian segregation analysis revealed that only backcross mice segregating the newly acquired Fv-2-linked endogenous ecotropic provirus had endogenous ecotropic transcripts in spleen RNA. Examination of different tissues of B6.S mice showed that Emv-18 transcription was highest in spleen and bone marrow, tissues in which Fv-2 has been shown to function. These results support the conclusion that chromosomal location is an important factor controlling Emv-18 expression in B6.S mice. We also report the presence in the spleen of a novel xenotropic virus transcript detectable only in B6.S mice.

摘要

通过Northern印迹分析检测了Fv - 2同源小鼠品系中内源性逆转录病毒序列的表达。在B6.S（Fv - 2ss）小鼠的脾脏总RNA中观察到内源性亲嗜性病毒转录本。在B6.S的Fv - 2rr同源亲本C57BL/6的脾脏RNA中未检测到内源性亲嗜性转录本，在C57BL/10（Fv - 2rr）和B10.C（Fv - 2ss）同源品系的脾脏中也未检测到。孟德尔分离分析表明，只有分离出新获得的与Fv - 2连锁的内源性亲嗜性前病毒的回交小鼠，其脾脏RNA中才有内源性亲嗜性转录本。对B6.S小鼠不同组织的检测表明，Emv - 18转录在脾脏和骨髓中最高，而Fv - 2已被证明在这些组织中发挥作用。这些结果支持以下结论：染色体定位是控制B6.S小鼠中Emv - 18表达的一个重要因素。我们还报告了在脾脏中存在一种仅在B6.S小鼠中可检测到的新型异嗜性病毒转录本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/1cb6e4e8a676/jvirol00118-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/c3b9b01217b5/jvirol00118-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/d6c5410edd6c/jvirol00118-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/af2664c6370d/jvirol00118-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/1cb6e4e8a676/jvirol00118-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/c3b9b01217b5/jvirol00118-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/d6c5410edd6c/jvirol00118-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/af2664c6370d/jvirol00118-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb11/254897/1cb6e4e8a676/jvirol00118-0068-a.jpg

相似文献

1
Tissue-specific expression of the newly acquired ecotropic Emv-18 provirus in Fv-2 congenic mice.新获得的亲嗜性Emv-18前病毒在Fv-2同源近交系小鼠中的组织特异性表达。
J Virol. 1985 Jul;55(1):54-9. doi: 10.1128/JVI.55.1.54-59.1985.
2
Linkage of the Fv-2 gene to a newly reinserted ecotropic retrovirus in Fv-2 congenic mice.Fv-2基因与Fv-2同源基因小鼠中新插入的亲嗜性逆转录病毒的连锁关系。
J Virol. 1983 Sep;47(3):471-7. doi: 10.1128/JVI.47.3.471-477.1983.
3
Fv-2 locus controls expression of Friend spleen focus-forming virus-specific sequences in normal and infected mice.Fv-2基因座控制正常和感染小鼠中弗瑞德脾集落形成病毒特异性序列的表达。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5809-12. doi: 10.1073/pnas.76.11.5809.
4
A unique sequence related to the ecotropic murine leukemia virus is associated with the Fv-4 resistance gene.与亲嗜性鼠白血病病毒相关的一个独特序列与Fv-4抗性基因有关。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):834-7. doi: 10.1073/pnas.81.3.834.
5
RB virus: a strain of Friend virus that produces a 'Friend virus-like' disease in Fv-2rr mice.RB病毒：一种弗氏病毒株，可在Fv-2rr小鼠中引发“类弗氏病毒”疾病。
Virus Res. 1989 Oct;14(2):161-73. doi: 10.1016/0168-1702(89)90036-1.
6
Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus.Friend红白血病抗原。一种由脾集落形成病毒指定的病毒抗原，以及受Fv-2基因座控制的分化抗原。
J Exp Med. 1979 May 1;149(5):1152-67. doi: 10.1084/jem.149.5.1152.
7
Transgenic Fv-4 mice resistant to Friend virus.对Friend病毒有抗性的转基因Fv-4小鼠。
J Virol. 1993 Jul;67(7):4163-8. doi: 10.1128/JVI.67.7.4163-4168.1993.
8
Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in in utero-infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus.嗜亲性鼠白血病病毒在C58和AKR小鼠以及子宫内感染的CE/J小鼠中感染中枢神经系统细胞，使小鼠易受乳酸脱氢酶升高病毒的麻痹性感染。
J Virol. 1995 Jan;69(1):308-19. doi: 10.1128/JVI.69.1.308-319.1995.
9
The Fv-2 gene controls induction of erythroid burst formation by Friend virus infection in vitro: studies of growth regulators and viral replication.Fv - 2基因在体外通过Friend病毒感染控制红系爆式集落形成的诱导：生长调节因子与病毒复制的研究
J Gen Virol. 1985 Jan;66 ( Pt 1):83-96. doi: 10.1099/0022-1317-66-1-83.
10
Retroviral endogenous transcripts related to the envelope gene of Friend spleen focus-forming virus in normal mouse tissues.正常小鼠组织中与弗瑞德脾脏灶形成病毒包膜基因相关的逆转录病毒内源性转录本。
Arch Virol. 1986;90(1-2):15-28. doi: 10.1007/BF01314141.

引用本文的文献

1
B-Cell lymphoma induction by akv murine leukemia viruses harboring one or both copies of the tandem repeat in the U3 enhancer.携带U3增强子中串联重复序列一个或两个拷贝的Akv鼠白血病病毒诱导B细胞淋巴瘤
J Virol. 1998 Jul;72(7):5745-56. doi: 10.1128/JVI.72.7.5745-5756.1998.
2
Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.使用感染性逆转录病毒载体将细菌基因插入小鼠种系。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8587-91. doi: 10.1073/pnas.82.24.8587.
3
Mouse chromosome 9.小鼠9号染色体。

本文引用的文献

1
HISTOCOMPATIBILITY GENES OF MICE. V. FIVE NEW HISTOCOMPATIBILITY LOCI IDENTIFIED BY CONGENIC RESISTANT LINES ON A C57B 10 BACKGROUND.小鼠的组织相容性基因。V. 在C57B10背景上通过同源抗性品系鉴定出的五个新的组织相容性位点。
Transplantation. 1965 Mar;3:235-52. doi: 10.1097/00007890-196503000-00011.
2
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs.α和β微管蛋白mRNA编码的核苷酸及相应氨基酸序列。
Nature. 1981 Feb 19;289(5799):650-5. doi: 10.1038/289650a0.
3
Fv-2 locus controls the proportion of erythropoietic progenitor cells (BFU-E) synthesizing DNA in normal mice.
Mamm Genome. 1991;1 Spec No:S127-45. doi: 10.1007/BF00656490.
4
Mouse chromosome 9.小鼠9号染色体。
Mamm Genome. 1992;3 Spec No:S136-52. doi: 10.1007/BF00648427.
Fv-2基因座控制正常小鼠中合成DNA的红细胞生成祖细胞（BFU-E）的比例。
Cell. 1980 Jan;19(1):225-36. doi: 10.1016/0092-8674(80)90404-3.
4
Chromosomal position and activation of retroviral genomes inserted into the germ line of mice.插入小鼠生殖系的逆转录病毒基因组的染色体定位与激活
Cell. 1981 May;24(2):519-29. doi: 10.1016/0092-8674(81)90343-3.
5
Germ-line MuLV reintegrations in AKR/J mice.AKR/J小鼠中的生殖系MuLV重新整合
Nature. 1982 Apr 29;296(5860):865-8. doi: 10.1038/296865a0.
6
Linkage of the Fv-2 gene to a newly reinserted ecotropic retrovirus in Fv-2 congenic mice.Fv-2基因与Fv-2同源基因小鼠中新插入的亲嗜性逆转录病毒的连锁关系。
J Virol. 1983 Sep;47(3):471-7. doi: 10.1128/JVI.47.3.471-477.1983.
7
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein.弗氏脾脏集落形成前病毒感染性克隆的完整核苷酸序列：gp55是一种包膜融合糖蛋白。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5037-41. doi: 10.1073/pnas.80.16.5037.
8
Nucleotide sequence analysis establishes the role of endogenous murine leukemia virus DNA segments in formation of recombinant mink cell focus-forming murine leukemia viruses.核苷酸序列分析确定了内源性鼠白血病病毒DNA片段在重组水貂细胞灶形成性鼠白血病病毒形成中的作用。
J Virol. 1984 Jun;50(3):864-71. doi: 10.1128/JVI.50.3.864-871.1984.
9
Fluidity of a retrovirus genome.逆转录病毒基因组的流动性
J Virol. 1984 Jun;50(3):759-65. doi: 10.1128/JVI.50.3.759-765.1984.
10
Relationship between a retroviral germ line reintegration and a new mutation at the ashen locus in B10.F mice. Retroviral integration and an ashen mutation.
Virology. 1984 Feb;133(1):183-90. doi: 10.1016/0042-6822(84)90437-9.