Joint Diseases Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, P. R. China.
State Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, P. R. China.
ACS Biomater Sci Eng. 2024 Jun 10;10(6):3655-3672. doi: 10.1021/acsbiomaterials.4c00422. Epub 2024 May 14.
Slippery liquid-infused porous surface (SLIPS), inspired by the pitcher plant, exhibits excellent performances as it has a smooth surface and extremely low contact angle hysteresis. Biomimetic SLIPS attracts considerable attention from the researchers for different applications in self-cleaning, anti-icing, anticorrosion, antibacteria, antithrombotic, and other fields. Hence, SLIPS has shown promise for applications across both the biomedical and industrial fields. However, the manufacturing of SLIPS with strong bonding ability to different substrates and powerful liquid locking performance remains highly challenging. In this review, a comprehensive overview of research on SLIPS for medical applications is conducted, and the design parameters and common fabrication methods of such surfaces are summarized. The discussion extends to the mechanisms of interaction between microbes, cells, proteins, and the liquid layer, highlighting the typical antifouling applications of SLIPS. Furthermore, it identifies the potential of utilizing the controllable factors provided by SLIPS to develop innovative materials and devices aimed at enhancing human health.
滑液浸润多孔表面（SLIPS）受猪笼草启发，具有光滑的表面和极低的接触角滞后，因此具有出色的性能。仿生 SLIPS 因其在自清洁、抗结冰、防腐、抗菌、抗血栓和其他领域的不同应用而引起了研究人员的极大关注。因此，SLIPS 在生物医学和工业领域的应用都具有广阔的前景。然而，制造具有强键合能力的 SLIPS 到不同的基底和强大的液体锁定性能仍然极具挑战性。在这篇综述中，对 SLIPS 在医学应用方面的研究进行了全面的概述，并总结了这些表面的设计参数和常见的制造方法。讨论扩展到了微生物、细胞、蛋白质和液层之间相互作用的机制，强调了 SLIPS 的典型抗污应用。此外，它还确定了利用 SLIPS 提供的可控因素来开发旨在增强人类健康的创新材料和设备的潜力。
