鉴定三种新型非移动黏菌素耐药决定因子 NMCR-3、NMCR-4 和 NMCR-5：分别与 MCR-3、MCR-7 和 MCR-5 前体相关。
Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively.
机构信息
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Key Laboratory of Environment Correlative Dietology, College of Biomedicine and Health, College of Fisheries, Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Hubei Hongshan Laboratory, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Faculty of Public Health, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.
出版信息
Drug Resist Updat. 2024 Jul;75:101088. doi: 10.1016/j.drup.2024.101088. Epub 2024 Apr 26.
In this study, the progenitors of MCR-3, MCR-7 and MCR-5, namely NMCR-3, NMCR-4 and NMCR-5, were firstly discovered and indicating Aeromonas was a natural reservoir for MCR-3 and MCR-7. Furthermore, different evolutionary models for MCR-3, MCR-7 and MCR-5 were proposed.
在这项研究中，MCR-3、MCR-7 和 MCR-5 的前体，即 NMCR-3、NMCR-4 和 NMCR-5，首次被发现，表明气单胞菌是 MCR-3 和 MCR-7 的天然储库。此外，还提出了 MCR-3、MCR-7 和 MCR-5 的不同进化模型。
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