黏菌素耐药基因mcr-1在意大利的传播：一株耐黏菌素大肠杆菌血源分离株中mcr-1.2等位基因变体的特征分析
Spread of colistin resistance gene mcr-1 in Italy: characterization of the mcr-1.2 allelic variant in a colistin-resistant blood isolate of Escherichia coli.
作者信息
Simoni Serena, Morroni Gianluca, Brenciani Andrea, Vincenzi Chiara, Cirioni Oscar, Castelletti Sefora, Varaldo Pietro E, Giovanetti Eleonora, Mingoia Marina
机构信息
Unit of Microbiology, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Unit of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
出版信息
Diagn Microbiol Infect Dis. 2018 May;91(1):66-68. doi: 10.1016/j.diagmicrobio.2017.12.015. Epub 2017 Dec 24.
mcr-1.2, an allelic variant of the transferable colistin resistance gene mcr-1, was characterized in a colistin-resistant blood isolate of Escherichia coli. It was harbored by an IncX4-type plasmid (33,293 bp). Despite its low prevalence, the potentially worrying spread of the mcr-1 gene, particularly its mcr-1.2 variant, in Italy requires increasing surveillance.
mcr-1.2是可转移的黏菌素抗性基因mcr-1的一个等位变体，在一株耐黏菌素的大肠杆菌血液分离株中得到鉴定。它由一个IncX4型质粒（33293 bp）携带。尽管其流行率较低，但mcr-1基因，尤其是其mcr-1.2变体在意大利的潜在令人担忧的传播情况需要加强监测。
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