巴西有机蜂蜜对口腔微生物的抗菌和抗生物膜活性。
Antimicrobial and antibiofilm activities of Brazilian organic honey against oral microorganisms.
机构信息
Department of Biosciences, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901 - Areião, Piracicaba, SP, 13414-903, Brazil.
Graduate Program in Integrated Dental Sciences, School of Dentistry, University of Cuiabá, Cuiabá, MT, 78065-900, Brazil.
出版信息
Braz J Microbiol. 2024 Sep;55(3):2285-2292. doi: 10.1007/s42770-024-01343-9. Epub 2024 May 15.
OBJECTIVE
To evaluate the antimicrobial activity of Brazilian honeys against oral microorganisms.
DESIGN
Organic honeys (OH-1 to OH-8) were diluted (%-w/v) and sterilized by filtration. Antimicrobial activity was defined by determining MIC and CBM against oral Streptococcus. The component responsible for the antimicrobial action was defined by a catalase assay. Antibiofilm activity was evaluated against the monospecies biofilm of Streptococcus mutans (ATCC 700610).
RESULTS
OHs showed antimicrobial activity principally OH-1, OH-2, OH-3, and OH-7 with MIC values ranging between 10 and 25%. The mechanism of action occurs mainly by hydrogen peroxide produced by honey enzymes. OH-1, OH-2, and OH-7 showed total biofilm destruction at low concentrations.
CONCLUSION
Brazilian honeys have promising antimicrobial and antibiofilm activity with the potential to control oral microbiota.
目的
评估巴西蜂蜜对口腔微生物的抗菌活性。
设计
有机蜂蜜（OH-1 至 OH-8）经稀释（%-w/v）并过滤消毒。通过测定对口腔链球菌的 MIC 和 CBM 来定义抗菌活性。通过过氧化氢酶测定法确定抗菌作用的成分。评估了抗单物种变形链球菌生物膜的活性（ATCC 700610）。
结果
OH 表现出抗菌活性，主要是 OH-1、OH-2、OH-3 和 OH-7，MIC 值在 10-25%之间。作用机制主要是由蜂蜜酶产生的过氧化氢引起的。OH-1、OH-2 和 OH-7 在低浓度下显示出完全的生物膜破坏。
结论
巴西蜂蜜具有有前景的抗菌和抗生物膜活性，有可能控制口腔微生物群。
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