Cao Fang, Yang Fushuang, Li Jian, Guo Wei, Zhang Chongheng, Gao Fa, Sun Xinxin, Zhou Yi, Zhang Wenfeng
School of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China.
College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China.
Diabetol Metab Syndr. 2024 May 14;16(1):101. doi: 10.1186/s13098-024-01346-4.
The link between diabetes and dementia risk is not well understood. This study evaluates the factors linking diabetes to dementia onset, providing guidance for preventing dementia in diabetic patients.
This analysis utilized databases such as PubMed, Embase, Web of Science, and the Cochrane Library to review literature from January 31, 2012, to March 5, 2023. Articles were rigorously assessed using specific inclusion and exclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies. Data analysis was performed with STATA 15.0.
The study analyzed 15 articles, covering 10,103,868 patients, with 8,821,516 diagnosed with diabetes. The meta-analysis reveals a substantial association between diabetes and an increased risk of dementia [RR: 1.59, 95%CI (1.40-1.80), P < 0.01, I²=96.4%]. A diabetes duration of less than five years is linked to a higher dementia risk [RR: 1.29, 95%CI (1.20-1.39), P < 0.01, I²=92.6%]. Additionally, hypoglycemia significantly raises dementia risk [RR: 1.56, 95%CI (1.13-2.16), P < 0.01, I²=51.5%]. Analyses of blood sugar control, glycated hemoglobin, and fasting blood sugar indicated no significant effects on the onset of dementia.
Diabetes notably increases dementia risk, particularly where diabetes duration is under five years or hypoglycemia is present.
The research protocol was registered with PROSPERO and assigned the registration number CRD42023394942.
糖尿病与痴呆风险之间的联系尚未完全明确。本研究评估了将糖尿病与痴呆发病联系起来的因素，为糖尿病患者预防痴呆提供指导。
本分析利用了诸如PubMed、Embase、科学网和考克兰图书馆等数据库，回顾了2012年1月31日至2023年3月5日的文献。使用特定的纳入和排除标准对文章进行严格评估。采用纽卡斯尔-渥太华量表（NOS）评估研究质量。使用STATA 15.0进行数据分析。
该研究分析了15篇文章，涵盖10103868名患者，其中8821516名被诊断患有糖尿病。荟萃分析显示糖尿病与痴呆风险增加之间存在显著关联[风险比（RR）：1.59，95%置信区间（CI）（1.40 - 1.80），P < 0.01，I² = 96.4%]。糖尿病病程少于五年与较高的痴呆风险相关[RR：1.29，95%CI（1.20 - 1.39），P < 0.01，I² = 92.6%]。此外，低血糖显著增加痴呆风险[RR：1.56，95%CI（1.13 - 2.16），P < 0.01，I² = 51.5%]。对血糖控制、糖化血红蛋白和空腹血糖的分析表明对痴呆发病无显著影响。
糖尿病显著增加痴呆风险，特别是在糖尿病病程少于五年或存在低血糖的情况下。
该研究方案已在国际前瞻性系统评价注册库（PROSPERO）注册，并被分配注册号CRD42023394942。
