Zachary J F, Smith A R
Am J Vet Res. 1985 Apr;46(4):821-30.
Immune responses and hematologic alterations were investigated in splenectomized pigs after IM inoculation with Eperythrozoon suis. Early hematologic alterations were massive parasitism of RBC, severe hypoglycemia, moderate bilirubinemia, and mild anemia; later findings included severe anemia, minimal parasitism of RBC, spontaneous agglutination of RBC at 25 C and 4 C which was reversible at 37 C, transient thrombocytopenia, and mild bilirubinemia. The humoral immune responses consisting of a transitory hyperglobulinemia and increase of indirect hemagglutination (IHA) titers against E suis were attributed to immunoglobulin M cold agglutinins. Cell-mediated immune responses, measured by phytohemagglutinin- and pokeweed mitogen-induced lymphocyte blastogenesis, were reduced after massive parasitemia. Blastogenesis induced by Escherichia coli lipopolysaccharide mitogen was increased before the hyperglobulinemia and an increase in IHA titer. There was an increase in the uptake of [3H]thymidine by lymphocytes cultured without mitogens after the decline in total globulin concentration and IHA titer.
对经肌肉注射接种猪附红细胞体的脾切除猪的免疫反应和血液学改变进行了研究。早期血液学改变包括红细胞大量寄生、严重低血糖、中度胆红素血症和轻度贫血；后期发现包括严重贫血、红细胞极少寄生、红细胞在25℃和4℃时自发凝集（在37℃时可逆）、短暂血小板减少和轻度胆红素血症。由短暂性高球蛋白血症和针对猪附红细胞体的间接血凝（IHA）效价升高组成的体液免疫反应归因于免疫球蛋白M冷凝集素。在大量虫血症后，通过植物血凝素和商陆有丝分裂原诱导的淋巴细胞增殖来衡量的细胞介导免疫反应降低。在高球蛋白血症和IHA效价升高之前，由大肠杆菌脂多糖有丝分裂原诱导的增殖增加。在总球蛋白浓度和IHA效价下降后，在无有丝分裂原培养的淋巴细胞中[3H]胸腺嘧啶核苷摄取增加。
