Center for Reproductive Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2024 Apr 29;15:1343803. doi: 10.3389/fendo.2024.1343803. eCollection 2024.
This study aims to retrospectively estimate cumulative reproductive outcomes in women with primary ovarian insufficiency (POI) in assisted reproductive technology (ART) therapy.
A total of 139 patients diagnosed with POI were reviewed in this study. Firstly, they were divided into two groups according to oocyte origin: using their own oocytes (OG group) or accepting oocyte donations (OD I group). Secondly, the patients were split depending on the pregnancy outcome. In the OG group, nine patients decided to use others' oocytes after a failure of attempting to use their own, and this population was the oocyte donation II group (OD II group).
There were 88 patients who used their own oocytes, while 51 patients accepted oocyte donations. In the OG group, there are only 10 (7.2%) patients who got pregnant, and patients in the OD group had worse hormone levels (FSH 71.37 ± 4.18 vs. 43.98 ± 2.53, AMH 0.06 ± 0.04 vs. 1.15 ± 0.15, and AFC 0.10 ± 0.06 vs. 1.15 ± 0.15) and more years of infertility (5.04 ± 0.48 vs. 3.82 ± 0.30), which explained why they choose oocyte donation. In all the three groups, baseline characteristics were comparable between pregnant women and non-pregnant women. Of the 10 pregnant patients in the OG group, four of them used luteal-phase short-acting long protocol and had pregnancies successfully in their first cycles.
Ovarian stimulation in POI women requires more cost and time. For those with a stronger desire to have genetic offspring, luteal-phase short-acting long protocol may help them obtain pregnancy rapidly.
本研究旨在回顾性评估原发性卵巢功能不全（POI）患者接受辅助生殖技术（ART）治疗的累积生殖结局。
本研究共回顾性分析了 139 例 POI 患者。首先，根据卵母细胞来源将患者分为两组：使用自身卵母细胞（OG 组）或接受卵母细胞捐赠（OD I 组）。其次，根据妊娠结局将患者进一步分组。在 OG 组中，9 例患者在尝试使用自身卵母细胞失败后决定使用他人卵母细胞，该人群为卵母细胞捐赠 II 组（OD II 组）。
88 例患者使用自身卵母细胞，51 例患者接受卵母细胞捐赠。在 OG 组中，仅有 10 例（7.2%）患者妊娠，而接受捐赠卵母细胞的患者激素水平较差（FSH 71.37±4.18 与 43.98±2.53，AMH 0.06±0.04 与 1.15±0.15，AFC 0.10±0.06 与 1.15±0.15），不孕年限更长（5.04±0.48 与 3.82±0.30），这解释了她们选择卵母细胞捐赠的原因。在所有三组中，妊娠组与非妊娠组的基线特征相似。在 OG 组的 10 例妊娠患者中，有 4 例采用黄体期短效长方案，在首次周期成功妊娠。
POI 患者的卵巢刺激需要更多的成本和时间。对于那些有强烈生育遗传后代愿望的患者，黄体期短效长方案可能有助于她们快速获得妊娠。
