Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq.
Ir J Med Sci. 2024 Oct;193(5):2209-2216. doi: 10.1007/s11845-024-03711-8. Epub 2024 May 15.
Neuregulin-1(NRG-1) is a protein that belongs to the group of epidermal growth factors. It plays vital roles in anti-fibrotic effects on the myocardium. The current paper explores the role of NRG-1 in type 2 diabetes mellitus (T2DM) and its relation to atherogenic index as a factor for increasing cardiovascular disease(CVD) risk.
In this study, 79 diabetes mellitus patients are independent insulin. These patients consisted of 53 females and 26 males their age were ranged 40-67 years. They were divided into two groups depending on the atherogenic index of plasma (AIP). Group I including48 diabetic patient with high risk of CVD and group II including 31 diabetic patients without risk CVD. Forty healthy individuals were included as control.
When compared to the control group, the serum levels of NRG-1 were significantly lower (p = 0.01). Additionally, group I had a much lower NRG-1level than group II. The results of multiple stepwise regression showed that the only independent predictor for NRG-1 level prediction was AIP (β = - 0.600, P = 0.040). When comparing the diabetic patients with high risk factors for CVD to the healthy subject group, the AUC was outstanding (AUC = 0.889, P = 0.001) and had a high diagnosis.
We proved low NRG-1 levels in diabetic patients and the association of highest NRG-1 amounts to a better AIP. Moreover, the measurement of NRG-1 levels could be beneficial as laboratory markers to monitor for increasing CVD risk in type 2 diabetes mellitus.
神经调节蛋白 1（NRG-1）是一种属于表皮生长因子族的蛋白质。它在心肌抗纤维化作用中发挥着重要作用。本论文探讨了 NRG-1 在 2 型糖尿病（T2DM）中的作用及其与动脉粥样硬化指数（AIP）的关系，AIP 是增加心血管疾病（CVD）风险的一个因素。
在这项研究中，79 名独立使用胰岛素的糖尿病患者，其中 53 名女性，26 名男性，年龄在 40-67 岁之间。根据血浆 AIP 将这些患者分为两组。第一组包括 48 名有 CVD 高风险的糖尿病患者，第二组包括 31 名无 CVD 风险的糖尿病患者。40 名健康个体作为对照组。
与对照组相比，NRG-1 的血清水平明显降低（p=0.01）。此外，第一组的 NRG-1 水平明显低于第二组。多元逐步回归分析结果表明，NRG-1 水平的唯一独立预测因子是 AIP（β=-0.600，P=0.040）。当将 CVD 高危因素的糖尿病患者与健康受试者组进行比较时，AUC 非常出色（AUC=0.889，P=0.001），且具有较高的诊断价值。
我们证明了糖尿病患者 NRG-1 水平较低，并且 NRG-1 水平最高与更好的 AIP 相关。此外，NRG-1 水平的测量可能作为实验室标志物有助于监测 2 型糖尿病患者 CVD 风险的增加。
