质子激活的 G 蛋白偶联受体在炎症中的免疫调节作用。

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

出版信息

Curr Med Sci. 2024 Jun;44(3):475-484. doi: 10.1007/s11596-024-2872-4. Epub 2024 May 15.

DOI:10.1007/s11596-024-2872-4

PMID:38748372

Abstract

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

摘要

质子激活的 G 蛋白偶联受体（GPCRs）最初是由 Ludwig 于 2003 年发现的，广泛分布于各种组织中。这些受体已被发现可调节几种炎症性疾病中的免疫系统，包括炎症性肠病、特应性皮炎和哮喘。质子激活的 GPCR 属于 G 蛋白偶联受体家族，可检测细胞外 pH 值的变化。这种检测会触发细胞内的下游信号通路，最终影响免疫细胞的功能。在本综述中，我们专门研究了炎症条件下质子激活的 GPCR 对免疫反应的影响。